摘要
目的采用计算机处理核磁共振图像(magnetic resonance imaging,MRI),研究阿尔茨海默氏病(Alzheime's disease,AD)患者的灰质萎缩区域。方法采用逐像素形态学(voxeI-based morphometry,VBM)方法。结果和正常老年人对照组相比,AD病人的海马、海马旁回、内嗅皮层、杏仁体、尾状核头部、颞中回、扣带回、顶下小叶、岛叶和前额叶背外侧区双侧萎缩；右侧丘脑枕、颞上回、顶上小叶不同程度萎缩,而感觉运动皮层、小脑和枕叶相对保持完好。结论 VBM方法克服了以往使用人工勾画感兴趣区(ROI)方法的可重复性差,费时等缺点,可以客观、自动和全面地分析AD的灰质减少,具有良好的临床应用前景。
Objective To explore the gray matter loss of Alzheimer＇s disease （AD） patients by processing the magnetic resonance imaging （MRI） with computer. Method A voxel-based morphometry （VBM） method was applied in this study. Result Bilateral loss of gray matter in AD patients was found in the entorhinal/ hippocampal/parahippocampal cortex areas, amygdala, the head of the caudate nucleus, middle temporal gyrus, cingulate gyrus, inferior parietal Iobule, insula and dorsolateral prefrontal cortex. Furthermore, area of right pulvinar, cortex of superior temporal gyrus and superior parietal Iobule reduced significantly. On the other hand, somatosensory/motor cortex, cerebellum and occipital lobe were relatively intact. Conclusion VBM overcomes the shortcomings of region of interesting（ROI）, such as time-consuming, dependence on observer, and poorly reproducible, and can analyze the gray matter loss objectively and automatically and have a good perspective for clinical applications.
出处
《航天医学与医学工程》
CAS
CSCD
北大核心
2006年第1期1-5,共5页
Space Medicine & Medical Engineering
基金
Supported by the National Natural Science Foundation of China(90209030)
关键词
阿尔蒋海默氏病
磁共振成像
感兴趣区方法
逐像素形态学分析
Alzheimer＇s disease （AD）
magnetic resonance imaging （ MRI ）
regions of interest method
voxel-based morphometry
