摘要
CIN85与CD2AP构成了一个接头蛋白家族,在个体发育中担当重要角色并和多种疾病的病理机制相关。它们在功能结构域的序列上有很高的相似性,并具有细胞骨架蛋白的特点。近来研究表明CIN85在受体酪氨酸激酶(RTK)的内吞与降解、细胞凋亡、细胞局部黏附等许多生物学过程中发挥重要作用。
CIN85 and CD2AP comprise a new family of adaptor proteins that plays important roles in animal development and diseases. They share a high sequence similarity in several functional domains that exhibit unique scaffolding function. Recent data suggest that the scaffolding function of CIN85 may control multiple cellular functions, such as down-regulation of receptor tyrosine kinases （RTK）, regulation of apoptosis, and modulation of cell adhesion.
出处
《细胞生物学杂志》
CSCD
2006年第1期1-4,共4页
Chinese Journal of Cell Biology
