摘要
糖尿病肾病的病理变化表现为肾小球、肾小管肥大,肾小球肾小管基膜增厚,肾小球系膜区细胞外基质堆积以及肾小球硬化。生长因子是具有刺激细胞生长作用的细胞因子,包括转化生长因子-β(TGF-β)、胰岛素样生长因子(IGF)、表皮生长因子(EGF)、血管内皮生长因子(VEGF)、成纤维细胞生长因子(FGF)、结缔组织生长因子(CTGF)、神经生长因子(NGF)、血小板源性生长因子(PDGF)等,在细胞肥大、细胞增殖、细胞外基质堆积等方面发挥作用。
Although the pathogenetic mechanism of diabetic nephropathy has not been elucidated, some growth factors have been suggested to contribute to its progression. Growth factors, such as VEGF, TGF-beta, IGF, PDGF, CTGF, EGF, FGF and NGF, play important roles in glomerular/tubular hypertrophy, glomerular basement membrane thicking, extracellular matrix expansion and glomerulosclerosis.
出处
《武汉大学学报（医学版）》
CAS
2006年第1期130-134,共5页
Medical Journal of Wuhan University
关键词
糖尿病
肾病
生长因子
Diabetes Mellitus
Diabetic Nephropathy
Growth Factor
