摘要
目的:探讨大鼠抑郁症模型海马容积改变的特点及其病理特征。方法:对大鼠抑郁症模型组、治疗组和对照组行MRI检查,测量两侧海马容积,采用免疫组化方法观察抑郁症大鼠模型组和治疗组海马及额叶5-HT、NSE、GFAP的变化。结果:①MRI显示抑郁症大鼠脑纵裂增宽,扩大且左侧海马容积小于对侧;②氟西汀治疗组未见明显海马容积及形态改变;③模型组海马及额叶NSE表达明显减弱,额叶的GFAP表达明显减弱;治疗组NSE及GFAP的表达有明显增强。结论:抑郁症时存在独特的病理变化,在一定程度上支持神经影像学的发现。
Objective： To study the MRI volume of the hippocampus and pathological characteristics in rats with depression. Methods： A rat model of depression was established. The volume of the hippocampus was observed by MRI. The NSE, GFAP and 5-HT in the hippocampus and the frontal lobe were assayed, using the technique of immunohisochemistry. Results： ① MRI suggested that brain cleft was enlarged and widened in depressed rats, and the volume of the left hippocampus in depressed rats was smaller than the volume of the right. ② The enlarged and widen fissure was not observed after the treatment of Fluovetine. ③ Less expressions of the NSE in the hippocampus and the frontal lobe were observed in the depressed rats, as well as less expressions of glial fibrillary acidic protein （GFAP） in the frontal lobe were observed in depressed rats. Fluovetine could increase the levels of GFAP and NSE in the brain of depressed rats. Conclusion： These results revealed that the major depression induces special histopathological changes of both neuron and glial cells in the frontal lobe and the hippocampus, and that will contribute to the interpretation of neuroimaging findings.
出处
《武汉大学学报（医学版）》
CAS
2006年第1期83-86,i0004,共5页
Medical Journal of Wuhan University
