摘要
核受体liverXreceptors(LXRs)可抑制糖异生关键酶的表达,抑制肝糖异生,限制肝糖原输出,提高肝糖利用率。同时可促进葡萄糖转运子4的基因转录,提高外周组织对葡萄糖的摄取。因而在糖代谢过程中具有重要作用。此外,LXRs还通过调节胰岛素的合成和分泌、炎症因子的表达及糖皮质激素活性等方面影响糖尿病的发生、发展。因此,LXRs有望成为新的糖尿病治疗靶点。
Liver X receptors（LXRs） can reduce hepatic glucose production by inhibiting key enzymes that promote gluconeogenesis,lirnit hepatic glucose output and enhance hepatic glucose utilization. In addition, LXRs promote the gene transcription of glucose transporter 4 and increase glucose uptake in peripheral tissue. LXRs seem to play an important role in the regulation of glycometabolism. Activated LXRs can influence the pathogenesis and progress of diabetes by regulating the synthesis and secretion of insulin, expression of inflammatory cytokines and glucocorticoid action. LXRs may be a new target treatment of diabetes.
出处
《国际内分泌代谢杂志》
2006年第1期43-44,53,共3页
International Journal of Endocrinology and Metabolism
