摘要
Apelin是孤独G蛋白偶联受体APJ的内源性配体,在组织中分布广泛,具有降低血压、增强心肌收缩力、调节水盐平衡、促进垂体激素释放及调节免疫等多种生物学效应。最近的研究表明,apelin是一种脂肪细胞因子,其表达与肥胖明显相关,可抑制高血糖刺激的胰岛素分泌。因此,apelin是一种重要的生理调节肽。
Apelin is an endogenous ligand for the orphan G protein-coupled APJ receptors.The distribution of the apelin peptides and their receptors are widespread in human tissues. Apelin has multiple biological effects such as lowering blood pressure, increasing cardiac contractihty, regulating body fluid homeostasis, enhancing pituitary hormone release and modulating immunization.The recent studies demonstrate that apehn is a obesity-associated adipocyte cytokine, which inhibits glucose-stimulated insulin secretion. Therefore apelin is a novel important bioactive peptide.
出处
《国际内分泌代谢杂志》
2006年第1期17-19,共3页
International Journal of Endocrinology and Metabolism
基金
国家自然科学基金资助项目(30270631
30370671)
国家教委春晖计划资助项目(200356)
