摘要
目的:了解国内外近期运动与免疫研究进展状况。资料来源:应用计算机检索Medline1988-01/2004-12的关于运动与免疫的文章,检索词“exercise,immunity”,限定文章语言种类为英文。资料选择:共搜索1001条文献,对资料进行初审,选出与运动免疫相关的文献,通过摘要查找全文。资料提炼:从收集到的文献中,筛选出细胞免疫、细胞因子等有关运动免疫的相关文献13篇用于综述。资料综合:运动对免疫功能的影响取决于运动的强度和时间。适度的运动对免疫功能起到有益的调节作用;而长时间大强度运动以及长期的强化训练,将会导致机体免疫抑制。运动对淋巴细胞的影响表现在数量变化和功能改变上。不同运动类型、运动强度、运动持续时间动员不同亚型自然杀伤细胞,运动中细胞因子发生明显变化,其变化与运动的种类、强度和持续时间有关。运动中有更多的免疫物质对免疫功能有着重要的影响。结论:运动可对淋巴细胞及其亚型、自然杀伤细胞、自然杀伤T细胞及细胞因子产生影响。大负荷运动可使细胞免疫受抑制,体液免疫增强,致使机体免疫失衡。同时有必要对免疫相关的物质进行研究,以进一步明确运动与免疫的关系。
OBJECTIVE： To understand the developing status of recent study in exercise and immunity at home and abroad.
DATA SOURCES： We searched in Medline for articles on exercise and immunity from January 1988 to December 2004 with the key words of ＂ex- ercise, immunity＂ in English.
STUDY SELECTION： 1 001 pieces of literature were found altogether, These materials were examined for the first time and those related to exercise and immunity was selected. Relevant full texts were searched through abstracts.
DATA EXTRACTION： About 13 pieces of literature concerning exercise and immunity were screened out such as cellular inanunity and cytokine, etc. from collected literature for reviews.
DATA SYNTHESIS： The impact of exercise on immune function depended on the intensity and length of exercise, Moderate exercise had a beneficial regulating effect on immune function; but exercise with heavy intensity lasting for a long time and a long-term intensified exercise would lead to the immunosuppression of the body. The effect of exercise on lymphocytes showed in the changes of quantity and function. Different subtype natural killer cells were used in different type, exercise intensity and duration. Cytokines changed significantly in exercise, and its change was related with the type, intensity and duration of exercise, More immune substance had important effect on immune function in exercise.
CONCLUSION： Exercise will impact lymphocyte and its subtype, nature killer cells, nature killer T-cells and cell factors. Heavy-load exercise will suppress the immunity of the cells and enhance humoral immunity, thus resulting in an imbalance of body immunity. Meanwhile, it is necessary to make a study of substance relevant to immunity so as to make clear the relationship between exercise and immunity.
出处
《中国临床康复》
CAS
CSCD
北大核心
2006年第4期148-149,共2页
Chinese Journal of Clinical Rehabilitation
