摘要
背景与目的:胰腺囊实性乳头状瘤是罕见的儿童胰腺肿瘤,临床资料较少,对其临床特点及治疗缺乏经验。结合本组病例,总结经验,探讨小儿胰腺囊实性乳头状肿瘤的病理与临床特点。方法:回顾性分析2000～2005年在小儿外科手术及病理证实的8例患儿,结合文献分析小儿胰腺囊实性乳头状肿瘤的病理与临床特点。结果:8例患者中,女性7例,男性1例,年龄11～16岁,中位年龄12.5岁。该肿瘤在儿童多以腹胀、腹痛、腹块为首发症状,肿瘤位于胰头或胰尾。1例行肿瘤切除术,5例行远端胰腺切除术,1例行胰十二指肠切除术,1例仅行病理活检术。除1例失访外,余7例患者生存至今,随访2个月至4年,2例复发。镜下观察:8例肿瘤均以实性区、囊性区及乳头状突起为其特征。免疫组化阳性率:α抗胰蛋白酶100%(8/8),波形蛋白87.5%(7/8),神经元特异性烯醇化酶62.5%(5/8)。结论:胰腺囊实性乳头状肿瘤多见于青春期女孩,组织病理来源不清,属低度恶性,具有良性临床病程,手术治愈率高,预后良好。
BACKGROUND ＆ OBJECTIVE： Solid cystic papillary tumor （SCPT） of the pancreas in children is rare with limited references of its clinical features and treatment. Therefore, to estimate the clinicopathologic features of SCPT of the pancreas in children is necessary. METHODS： Clinical data of 8 children with pathologically confirmed SCPT of the pancreas, treated from 2000 to 2005 with surgery, were analyzed retrospectively. The clinicopathologic features were analyzed with literature review. RESULTS, All patients were girls but one, with the average age of 12.8 years. The chief complaints were burbulence, abdominal pain, and palpable mass. The tumors were mainly located in the head or tail of the pancreas. Of the 8 patients, 1 received local resection, 5 received distal pancreatectomy, 1 received pancreatico-duodenectomy, and 1 received only biopsy. Seven patients were followed-up for 2 months to 4 years and were still alive; 2 patients suffered recurrence. All cases showed solid with cystic areas and papillary protrusions. Immunohistochemically, the positive rates were 100% for alpha-antitrypsin, 87.5% for vinmentin, and 62.5% for neuronspecific enolase. CONCLUSIONS： SCPT of the pancreas occurs predominantly in young girls, and its pathogenesis is still unknown. Surgical resection is usually curative, and the prognosis is good.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
2006年第2期220-223,共4页
Chinese Journal of Cancer
关键词
胰腺肿瘤
病理学
治疗
预后
儿童
Pancreatic neoplasms
Pathology
Treatment
Prognosis Children
