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胃肠道间质瘤的诊治分析(附21例报告) 被引量：2

Diagnosis and Treatment of Gastrointestinal Stromal Tumors (Report of 21 Cases )
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摘要 目的探讨胃肠道间质瘤(GISTs)的临床表现、病理特点及诊断、治疗和预后。方法回顾性分析2002年1月至2004年3月期间收治的21例GISTs患者的临床和病理资料。结果主要临床表现为腹部不适或疼痛、消化道出血、腹部包块和贫血。术前无一例确诊。均接受手术治疗,术中均未见淋巴结肿大转移。肿瘤直径<5cm者有9例,5～10cm者有9例,>10cm者3例。常规病理检查见梭形细胞,最终依靠免疫组化染色确诊。良性5例,低度恶性14例,恶性2例;免疫组化检测CD117阳性18例,CD34阳性13例,而CD117阳性和(或)CD34阳性20例。随访3～30个月,平均11.5个月,随访率为100%,1例于术后13个月死亡,1例术后7个月出现肝转移,其余均无瘤生存。结论GISTs术前确诊非常困难,病理检查时发现非上皮性的梭形细胞肿瘤应作常规免疫组化染色以确诊,手术切除为主要治疗方法。
作者 刘勇 易瑛 曾涛
机构地区 四川省德阳市人民医院普外科 德阳市口腔医院
出处 《中国普外基础与临床杂志》 CAS 2006年第1期100-101,共2页 Chinese Journal of Bases and Clinics In General Surgery
关键词 胃肠问质瘤 诊断 治疗
分类号 R735 [医药卫生—肿瘤]
  • 相关文献

参考文献12

  • 1Lewin KJ,Riddell RH,Weinstein WM,et al.Gastrointestinal pathology and its clinical implications [M].New York:Igaku-Shoin,1992:284-341
  • 2Mazur MT,Clark HB.Gastric stromal tumors.Reappraisal of histogenesis [J].Am J Surg Pathol,1983;7(6):507
  • 3Miettinen M,Lasota J.Gastrointestinal stromal tumors--de-finition,clinical,histological,immunohistochemical,and molecular genetic features and differential diagnosis [J].Virchows Arch,2001;438(1):1
  • 4唐军.胃肠运动起搏器———Cajal间质细胞研究进展[J].国外医学（生理病理科学与临床分册）,2003,23(1):81-83. 被引量：37
  • 5Miettinen M,Blay JY,Sobin LH.Mesenchymal tumours of the stomach.WHO classification of tumours.Pathology and genetics of tumours of digestive system [M].Lyon:IARC Press,2000:39-42
  • 6刘勇.胃壁广泛病变的胃肠道间质瘤1例[J].中国实用外科杂志,2005,25(3):175-175. 被引量：1
  • 7刘晓红,马大烈,吴丽莉,白辰光,胡宏杰.原癌基因c-kit在胃肠道间质瘤中的表达及其临床意义[J].中华外科杂志,2002,40(4):277-279. 被引量：29
  • 8高冬霞,廖松林.胃肠道间质瘤[J].诊断病理学杂志,2002,9(5):299-301. 被引量：47
  • 9Sircar K,Hewlett BR,Huizinga JD,et al.Interstitial cells of Cajal as precursors of gastrointestinal stromal tumors [J].Am J Surg Pathol,1999;23(4):377
  • 10Blanks CD.Therapeutic options for gastrointestinal stromal tumors [J].Proc ASCO,2003:266-272

二级参考文献33

  • 1Mazur MT,Clark HB.Gastric stromal tumor:reappraisal of histogenesis.Am J Surg Pathol,1983,7(16):507-519.
  • 2Miettinen M,Lasota J.Gastrointestinal stromal tumor-definition,clinical,histological,immunohistochemical,and molecular genetic features and differential diagnosis.Virchows Arch,2001,438(1):1-12.
  • 3Sircar K,Hewlett BR,Huizinga JD,et al.Interstitial cells of Cajal as precursors for gastrointestinal stromal tumors.Am J Surg Pathol,1999,23(4):377-389.
  • 4Lewin KJ,Riddel RH,Weinstein WM,et al.Gastrointestinal pathology and its clinical implications.New York:Lgaku-Shoin,1992.284-341.
  • 5Seidal T, Edvardsson H. Expression of c-kit(CD117) and Ki67 provides information about the possible cell of origin and clinical course of gastrointestinal stromal tumors. Histopathology, 1999, 34:416-424.
  • 6Mazur MT, Clark HB. Gastric stromal tumors. Reappraisal of histogenesis. Am J Surg Pathol, 1983, 7: 507-519.
  • 7Kindblom LG, Remotti HE,Aldenborg F,et al. Gastrointestinal pacemaker cell tumor(GIPACT):gastrointestinal stromal tumors show phenotypic characteristics of the interstitial cells of Cajal. Am J Pathol,1998,152:1259-1269.
  • 8Hirota S,Isozaki K,Moriyama Y, et al. Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors. Science, 1998, 279:577-580.
  • 9Miettinen M, Lasota J. Gastrointestinal stromal tumors-definition,clinical,histological,immunohistochemical,and molecular genetic features and differential diagnosis. Virchows Arch,2001,438:1-12.
  • 10Tsuura Y, Hiraki H, Watanabe K, et al. Preferential localization of c-kit product in tissue mast cells, basal cells of skin, epithelial cells of breast, small cell lung carcinoma, and seminoma/dysgerminoma in human: immunohistochemical study of formalin-fixed, paraffin-embedded tissues. Virchows Arch, 1994, 424:135-141.

共引文献322

同被引文献17

  • 1皋岚湘,丁华野,邓永江,田玉旺,吴霞.乳腺癌组织bcl-2、P53和c-erbB-2蛋白表达和相互关系及意义[J].中华病理学杂志,1996,25(3):165-168. 被引量：40
  • 2赵成艳,马荣,王忠利,马恩龙,王丽红.非霍奇金淋巴瘤患者T细胞亚群、NK细胞检测的临床意义[J].中国免疫学杂志,2006,22(2):180-181. 被引量：26
  • 3叶颖江,王志强,王杉.胃肠间质瘤诊断和治疗进展[J].中华胃肠外科杂志,2007,10(1):91-94. 被引量：25
  • 4Nilsson B, Brimming P, Meis Kindblom JM, et al. Gastrointestinal stromal tumors: the incidence, prevalence, clinical course, and prognostication in the preimatinib mesylate era-a population-based study in western Sweden[J]. Cancer, 2005; 103(4) :821
  • 5D'Amato G, Steinert DM, McAuliffe JC, etal. Update on the biology and therapy of gastrointestinal stromal tumors[J]. Cancer Control, 2005; 12(1):44
  • 6Mazur MT, Clark HB. Gastric stromal tumors. Reappraisal of histogenesis [J]. Am J Surg Pathol, 1983; 7(6): 507
  • 7Nishida T, Hirota S. Biological and clinical review of stromal tumors in the gastrointestinal tract[J]. Histol Histopathol, 2000, 15(4):1293
  • 8Blay JY, Bonvalot S, Casali P, et al. Consensus meeting for the management of gastrointestinal stromal tumors. Report of the GIST Consensus Conference of 20-21 March 2004, under the auspices of ESMO[J].Ann Oncol, 2005; 16(4):566
  • 9Berman J, O'Leary TJ. Gastrointestinal stromal tumor workshop[J]. Hum Pathol, 2001,32(6):578
  • 10Benjamin RS, Rankin C, Fletcher C, etal. Phase Ⅲ doseran domized study of imatini Mesylate (ST1571)for GIST: intergroup S0033 early results(abstract 3271)[J].Proc Am Soc Clin Oncol, 2003; 22(1):814

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中国普外基础与临床杂志
2006年 第1期

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