摘要
目的探讨格拉司琼对腹腔镜胆囊切除手术（laparoscopic cholecystectomy，LC）后恶心、呕吐（postoperative nausea and vomiting，PONV）的预防作用。方法选择120例ASAⅠ-Ⅱ级LC，随机分为A、B、C组，双盲法于手术结束后分别静脉注射格拉司琼3mg（A组）、6mg（B组）和生理盐水6ml（C组），观察3组病入手术结束后0～4h、4～8h、8-24h、24～48h恶心、呕吐、头痛、头昏情况。结果A、B组术后各时段恶心、呕吐发生率比C组明显减少（Y=4．021，P=0．045；x^2=4．267，P=0．039），A、B2组之间比较差异无显著性；头痛、头昏发生率B组显著高于A组（x^2=4．021，P=0．045；x^2=4．267，P=0．039），B组头痛发生率与C组比较差异无显著性（x^2=2．813，P=0．094），B组头昏发生率高于C组（x^2=4．267，P=0．039）。结论静注3mg或6mg格拉司琼能明显减少LC术后恶心、呕吐的发生率，但剂量增大会增加副作用。
Objective To laparoscopic cholecystectomy （ LC）. observe the preventive effect of granisetron on postoperative nausea and vomiting （PONV） after Methods A total of 120 ASA Ⅰ - Ⅱ patients undergoing LC were randomly divided into 3 groups with 40 patients in each group. After operation, the Group A was given an intravenous injection of 3 mg granisetron, the Group B received 6 mg granisetron, and the Group C received 6 ml normal saline. The incidence of nausea, vomiting, headache, and dizziness of the 3 groups at 0 - 4 h, 4 - 8 h, 8 - 24 h, and 24 - 48 h after operation was observed. Results The incidence of PONV in the Group A and B was significantly lower than that in the Group C （ P 〈 0.05） , and no significant difference between the Group A and B was observed. The incidence of headache and dizziness was significantly higher in the Group B than in the Group A （X^2 = 4.021, P = 0. 045 ; X^2 = 4. 267, P = 0. 039 ）. There was no significant difference in the incidence of headache between the Group B and C （X^2=2. 813, P =0. 094）. The incidence of dizziness was higher in the Group B than in the Group C （X^2 =4. 267, P =0. 039）. Conclusions Intravenous administration of 3 mg and 6 mg granisetron can significantly decrease the incidence of PONV after LC. Use of granisetron at 6 mg has more side - effects of headache and dizziness.
出处
《中国微创外科杂志》
CSCD
2006年第1期41-42,共2页
Chinese Journal of Minimally Invasive Surgery
关键词
格拉司琼
腹腔镜胆囊切除术
恶心
呕吐
Granisetron
Laparoscopic cholecystectomy
Nausea
Vomiting
