摘要
目的:观察去骨瓣减压术对局灶性脑缺血大鼠脑水肿、血脑屏障(BBB)及脑血流(CBF)的影响,探讨该手术对缺血性脑损害的保护机制。方法:改良Koizumi′s法制作脑缺血大鼠动物模型,脑缺血后6h行去骨瓣减压术,分别在术后3和7d观察脑水肿和血脑屏障的变化,另持续观察缺血1h+去骨瓣减压2h的CBF变化。结果:去骨瓣减压术后半暗区CBF增加更加持久和有效,在术后第3天时BBB破坏范围明显缩小,术后第7天时脑水含量明显降低。结论:去骨瓣减压术对局灶性脑缺血的保护作用可能与增加半暗区CBF、改善BBB破坏和减轻脑水肿有关。
Aim： To explore the mechanisms of the protective effects of decompressive craniectomy on focal cerebral ischemia by investigating the changes of brain edema, BBB disruption and CBF. Methods： Focal cerebral ischemia was induced by using an endovascular occlusion technique focused on left middle cerebral artery （MCA）. Decompressive craniectomy was performed at insult side 6 h after ischemia. Brain edema and BBB disruption was detected at day 3 and 7 after surgery, and the changes of CBF in penumbra and core were also measured before and after decompressive procedure. Results： CBF in penumbra was increased significantly after decompressive craniectomy. Brain water content was decreased markedly and approached to normal level at day 7 and BBB disruption was significantly improved at day 3 after decompressive surgery. Conclusion： Decompressive craniectomy has protective effects on focal cerebral ischemia by the mechanisms of improving cerebral perfusion, preventing the BBB disruption and alleviating brain edema.
出处
《中国临床神经科学》
2006年第1期72-76,共5页
Chinese Journal of Clinical Neurosciences
基金
上海市卫生局科研基金资助课题(P8ZED003)
关键词
脑缺血
去骨瓣减压术
脑水肿
血脑屏障
脑血流
cerebral ischemia
decompressive craniectomy
brain edema
blood brain barrier（BBB）
cerebral blood flow（CBF）
