摘要
目的:探讨血糖对C反应蛋白(CRP)和可溶性细胞间黏附分子(sICAM1)的影响及其在腔隙性脑梗死(lacunarinfarction,LI)发病机制中的作用。方法:采用ELISA法对LI合并糖尿病和非合并糖尿病患者及正常人的血清CRP和sICAM1的表达进行检测。结果:糖尿病合并LI患者血清中sICAM1和CRP的水平高于非糖尿病合并LI患者,明显高于正常对照组;血糖与sICAM1、CRP呈正相关;LI灶的数目与患者血糖及sICAM1,CRP的水平呈正相关。结论:糖尿病加重了脑缺血炎症反应,其导致的sICAM1,CRP的高表达参与了LI微血管病变的损伤过程。
Aim：To explore the influences of blood sugar on expression of CRP and sICAM-1 as well as their effects on pathogenesis related to lacunar infarction. Methods： Expression of CRP and sICAM-1 was measured by two-layer antibody sandwich enzyme-linked immunosorbent assay （ELISA） in 31 cases of lacunar infarction with diabetes, 32 patients with lacunar infarction were without diabetes. Results： The expression levels of CRP and sICAM-1 were higher in LI with diabetes group than those in LI without diabetes and significantly higher than those of normal controls. There was a positive correlation between the levels of blood sugar and those of CRP as well as sICAM- 1 in patients serum. In addition, blood sugar, sICAM- 1 and CRP levels have great relation with the numbers of LI focus. ConcIusion： The extra burden of blood sugar aggravated the reaction of inflammation in brain and enhanced the expression of CRP and ICAM-1 which were led by extra burden of blood sugar and joined in the process of injury to microvessels in patients with LI.
出处
《中国临床神经科学》
2006年第1期37-40,共4页
Chinese Journal of Clinical Neurosciences
关键词
腔隙性脑梗死
糖尿病
C-反应蛋白
细胞间黏附分子
lacunar infarction （ LI ）
diabetes mellitus
C- reaction protein （CRP）
soluble intercellular adhesion molecule-1 （sICAM-1）
