期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

The interaction between cytarabine and vincristine on HL-60 cell line in vitro

The interaction between cytarabine and vincristine on HL-60 cell line in vitro
暂未订购
导出
摘要 Objective： To analyze the effect of cytarabine combined with vincristine on HL-60 cell line in vitro. Methods： The median-effect equation and MTr assay were used on HL-60. Results： The cytotoxic activity of cytarabine（Ara-C） and vincristine （VCR） used alone or in combination enhanced as drug concentration increased. The order of administration did not influence the cytotoxic activity of the combined antitumor drugs. The ratio of drug concentration was a factor to influence the killing effect. The interaction of the agents was synergistic at lower concentration, and antagonistic at higher concentration. Conclusion： The combined drugs interaction（CI 〈 1 ） was synergistic at lower concentration and antagonistic at higher concentration. The ratio of drug concentration is a significant factor that can influence the killing effect. Objective： To analyze the effect of cytarabine combined with vincristine on HL-60 cell line in vitro. Methods： The median-effect equation and MTr assay were used on HL-60. Results： The cytotoxic activity of cytarabine（Ara-C） and vincristine （VCR） used alone or in combination enhanced as drug concentration increased. The order of administration did not influence the cytotoxic activity of the combined antitumor drugs. The ratio of drug concentration was a factor to influence the killing effect. The interaction of the agents was synergistic at lower concentration, and antagonistic at higher concentration. Conclusion： The combined drugs interaction（CI 〈 1 ） was synergistic at lower concentration and antagonistic at higher concentration. The ratio of drug concentration is a significant factor that can influence the killing effect.
作者 Shu Chen Weixue Tang Shifeng Lou
机构地区 Department of Hematology
出处 《Journal of Nanjing Medical University》 2006年第1期17-20,共4页 南京医科大学学报（英文版）
关键词 HL-60 median-effect principle cymrabine VINCRISTINE combination index（CI） HL-60 median-effect principle cymrabine vincristine combination index（CI）
分类号 R329.2 [医药卫生—人体解剖和组织胚胎学]
  • 相关文献

参考文献1

二级参考文献9

  • 1Feuillard J, Schuhmacher M, Kohanna S, et al. Inducible loss of NF-κB activity is associated with apoptosis and bcl-2 down-regulation in Epstein-Barr virus-transformed B lymphocytes. Blood, 2000,95:2068-2075.
  • 2Wang CY, Cusack JC Jr, Liu R, et al. Control of inducible chemoresistance: enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-kappaB. Nat Med,1999,5:412-417.
  • 3El-Sabban ME, Nasr R, Dbaibo G, et al. Arsenic-interferon-α-triggered apoptosis in HTLV-transformed cells is associated with tax down-regulation and reversal of NF-κB activation. Blood, 2000,96:2849-2855.
  • 4Gong J,Traganos F, Darzynkiewicz Z. A selective procedure for DNA extraction from apoptosis cells applicable for gel electrophoresis and flow cytometry. Anal Biochem, 1994,218: 314-319.
  • 5Reuther JY,Reuther GW,Cortez D, et al. A requirement for NF-κB activation in Bcr-Abl-mediated transformation. Genes Dev, 1998,12:968-981.
  • 6Keller SA, Schattner EJ, Cesarman E. Inhibition of NF-κB induces apoptosis of KSHV-infected primary effusion lymphoma cells. Blood, 2000,96:2537-2542.
  • 7Estrov Z, Manna SK, Harris D, et al. Phenylarsine oxide blocks interleukin-1β-induced activation of the nuclear transcription factor NF-κB, inhibits proliferation, and induces apoptosis of acute myelogenous leukemia cells. Blood, 1999, 94:2844-2853.
  • 8Cusack JC Jr, Liu R, Houston M, et al. Enhanced chemosensitivity to CPT-11 with proteasome inhibitor PS-341: implications for systemic nuclear factor-κB inhibition. Cancer Res, 2001,61:3535-3540.
  • 9史剑慧,许小平,程文英,罗伟华,王健民,丁训杰.白血病细胞p53和bcl-2表达与化疗药物诱导凋亡的关系[J].中华内科杂志,2000,39(3):181-184. 被引量：8

共引文献10

Journal of Nanjing Medical University
2006年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部