摘要
目的观察大鼠颅脑损伤后不同频率刺激下脑干听觉诱发电位(BAEP)的变化,为早期临床诊断和法医学活体伤害鉴定提供实验依据。方法使用自制弹簧式小型生物打击机打击大鼠颅顶部,制造闭合性弥漫性颅脑损伤(TBI)模型。分别于伤后6H、12H、2D、4D以10HZ低刺激频率、50HZ高刺激频率记录大鼠脑干听觉诱发电位,将各组结果进行比较。结果TBI后50HZ高刺激频率下BAEP的2D、4D组波PL和6H、12H、2D、4D组-波IPL,较对照组延长(P<0.05)。各组之间10HZ低刺激频率下BAEP差异无统计学意义(P>0.05)。各组10HZ、50HZ刺激频率下BAEP PL比值中/、/、/、/、/比值无明显损伤后改变。结论高刺激频率下BAEP测试是早期诊断颅脑损伤的可靠方法,其敏感性优于低刺激频率下BAEP测试。
Objective To investigate the change of peak latency （PL）, interpeak latency （IPL） and peak latency ratio （PL ratio） of bralnstem auditory evoked potential （BAEP） with different stimulating frequencies after closed diffuse brain injuries of rat ,and provide experimental evidence for clinical diagnosis of traumatic brain injury in early stage and also for Forensic practice. Methods A rat model for closed diffuse brain injury was successfully constructed by hit the parietal bone with a spring-driven steel stick. The auditory brainstem response （ABR） evoked by clicking with low stimulating frequency of 10 Hz and high stimulating frequency of 50 Hz were respectively recorded at 6 h,12 h,2 d,4 d after brain injury. The results of experimented group were compared with those of control group. Results The2d,4d V PLandthe6h,12h,2d,4d Ⅲ-Ⅴ IPLofBAEPwith 50Hz stimulating frequency of model group became longer than those of control group （P〈0. 05）, but there was no significant difference observed between model and control group experimented with low stimulating frequency of 10 Hz （P〉0.05）. The PL ratio of Ⅲ/Ⅰ、Ⅳ/Ⅰ、Ⅴ/Ⅰ、Ⅳ/Ⅲ and Ⅴ/Ⅲ with different stimulating frequencies had no significant postinjury changes. Conclusion The high stimulating frequency of BAEP is a reliable test for diagnosis of TBI in early period. Its sensitivity is superior to the low simulating frequency.
出处
《四川大学学报（医学版）》
CAS
CSCD
北大核心
2006年第1期73-76,共4页
Journal of Sichuan University(Medical Sciences)
关键词
创伤性脑损伤
脑干听觉诱发电位
刺激频率
潜伏期
Traumatic brain injury Brainstem auditory evoked potential Stimulating frequencies Latency
