摘要
卡托普利对血管平滑肌细胞内ｐＨ影响１齐建华，章鲁２，王军，顾培坤，金正均，黄明智３（上海第二医科大学药理教研室，２计算机医学应用教研室，３上海市高血压研究所，上海２０００２５，中国）王新明（中国科学院上海细胞生物学研究所，上海２０００３１，中国）关键...
IM: To observe the effect of captopril (Cap) on
intracellular pH (pH i) in aortic smooth muscle cells (ASMC).
METHODS: Cultured ASMC derived from rat and rabbit aortae were
loaded with the fluorescent dye BCECF and pH i was determined using
digital image processing method. RESULTS: The pH i of untreated SHR
and WKY rats were 7 37±0 29 and 7 19±0 31, respec￣tively. Oral
Cap decreased pH i (7 11±0 26, P <0 05) and exaggerated pH
i response to angiotensin Ⅱ (Ang Ⅱ, 0 1 μmol·L -1 ) in ASMC
of SHR rats vs WKY rats (0 14±0 05 vs 0 21 ±0 05 pH
units, P <0 01). Cap in vitro had no effect on Ang Ⅱ
induced intracellular alkalinization in ASMC of rabbits. CONCLUSION:
Oral Cap inhibits Na +-H + exchange activity in ASMC of SHR rats.
出处
《中国药理学报》
CSCD
1996年第5期448-450,共3页
Acta Pharmacologica Sinica
关键词
胸主动脉
平滑骨
PH值
血管紧张素Ⅱ
卡托普利
thoracic aorta
cultured cells
inbred SHR rats
inbred WKY
rats
hydrogen
sodium
angiotensin Ⅱ
captopril
