摘要
右美沙芬对局灶脑缺血所致的ｃｆｏｓ蛋白表达的抑制作用包维丽，陆世铎，程介士，张安中（上海医科大学医学神经生物学国家重点实验室，上海２０００３２，中国）关键词脑缺血；原癌基因蛋白ｃｆｏｓ；免疫组织化学；右美沙芬目的：观察右美沙芬对局灶脑缺血所致的ｃ...
IM: To study the effect of
dextromethorphan (DM) in focal cerebral ischemia. METHODS: The c
fos protein was detected immuno￣histochemically in the brain of
rats after focal cerebral ischemia (induced by placing a nylon thread
in the lumen of the internal carotid artery) with and without
treatment with DM. RESULTS: Focal cerebral ischemia induced c fos
protein expression outside the core territory of the middle cerebral
artery (MCA) and neuronal damage in the core territory of the MCA.
There was an evident expression of c fos protein in the
ipsilateral regions outside the MCA territory (eg cingulate cortices,
piriform cortices and entorhinal cortices), and in the contralateral
regions of hippocampus after 4 h reperfusion following 1 h MCA
occlusion. But morphological results showed severe edema and neuronal
damage in the core territory and the ipsilateral hippocampus. DM
blocked both the c fos protein induction and neuronal damage in
all regions. CONCLUSION: DM reduced c fos protein expression and
blocked the neuronal damage after focal cerebral ischemia.
出处
《中国药理学报》
CSCD
1996年第5期418-420,共3页
Acta Pharmacologica Sinica
关键词
脑缺血
原癌基因蛋白
C-FOS
右美沙芬
cerebral ischemia
proto oncogene proteins c fos
immunohistochemistry
dextro￣methorphan
