摘要
报告１６例脾胃虚寒型和１５例肝胃不和型慢性胃炎患者胃粘膜的超微结构异常，以及分别用健脾温胃汤和疏肝和胃汤辨证治疗的效果。两型慢性胃炎共同的超微结构异常是浆细胞浸润和粘膜上皮细胞、主细胞和胃窦部粘液细胞不同程度的损伤。但两型的损伤也有明显不同，脾胃虚寒型主细胞的损伤主要是线粒体肿胀，而肝胃不和型主细胞和浆细胞的损伤主要是粗面内质网扩张。治疗后，大多数病例的超微结构异常恢复正常或明显改善，从超微结构上看，两种方剂的辨证疗效非常明显。提示：①中医对慢性胃炎的辨证分型有一定的现代超微病理学基础，②健脾温胃汤、疏肝和胃汤均能促进胃粘膜各种超微结构异常的恢复。
This article reports: ①the ultrastructural anomalies of gastric mucosa of chronic gastritis patients. 16 cases of them have the cold of insufficiency syndrome of the spleen and the stomach and 15 cases have the incoordination syndrome of the liver and the stomach:② the effects treated dialectically with invigorating the spleen and warming the stomach decoction and dispersing the stagnated liver-Qi and regulating the stomach decoction separately. The common ultrastructural. anomalies of two types of chronic gastritis are the infiltration of the plasma cells and the lesions of the mucosal epithelial cells,chief cells and antral mucous cells with widely varying degree. But, these lesions have also obvious different in the two types. In the cases with the cold of insufficiency syndrome of the spleen and the stomach,the predominant lesions of the chief cells are swollen mitochondria,but the incoordination syndrome of the liver and the stomach,of the chief cells and the plasma cells are the dilation of rough endoplasmic reticulum. After the treatment,the ultrastructural anomalies in most cases are reverted to nomality or improved obviously. The results of this study show that: ①ultrastructural lesions of all the cases have the same occurrence, but differ widely in the chief cells and the plasma cells in gastrric mucosa of the two types of chronic gastri- tis;②the effects treated dialectically with this two decoctions are ultrastructurally very obvious. This article discusses the mechanism producing the ultrastructural anomalies of chronic gastritis and the effects of this treatment.
基金
1994年甘肃省教委科研资助项目的临床研究部分
关键词
慢性
胃炎
辨证论治
超微结构
中医药疗法
Traditional Chinese medicine (TCM) Dialectical treatment Chronic gastritis Ultrastructure
