摘要
本文采用细胞涂片法,利用非特异性酯酶(ANAE)和酸性磷酸酶(ACP)反应。在35例中常见骨肿瘤和瘤样病变中显示巨噬细胞和多核巨细胞。结果表明:所有骨肿瘤和瘤样病变都含有数量不等的巨噬细胞和多核巨细胞。含巨噬细胞较多的病变,多核巨细胞也较多。巨噬细胞与多核巨细胞的ANAE和ACP反应相似,呈弥漫强阳性。这说明两者是有密切的关系。另一方面,从有些多核巨细胞的形态,也支持多核巨细胞是由许多单核巨噬细胞互相融合而成的观点。巨噬细胞和多核巨细胞无异型性,也未见核分裂,因而它们不可能是恶性细胞,而是机体对肿瘤的反应性细胞。基于这个观点,就不难理解本文所有骨病变都存在有巨噬细胞和多核细胞。经统计学分析,各类骨肿瘤和瘤样病变的巨噬细胞数有显著性差异。Ⅰ级骨巨细胞瘤的巨噬细胞数比Ⅱ级骨巨细胞瘤多。骨巨细胞瘤中的巨噬细胞样间质细胞可能是浸润到肿瘤中的巨噬细胞。
Macrophages (Mφ) and poly-nuclear giant cells (PGC) were demonstrated by acid α-naphthyl acetate esterase (ANAE) and acid phosphatase (ACP) reaction in cell smears of 35 cases of bone tumors and tumor-like lesions. The result indicated that there were various amounts of Mφ and in all lesions. The more Mφ the lesion contained, the more PGC it had. Strong and diffuse reactions to ANAE and ACP appeared both in Mφ and PGC. It seems that some relationship existed between Mφ and PGC. In addition, the morphology of PGC gave some clue to the hypothesis, that the PGC were resulted from the fusion of many mononuclear Mφ . Atypia and mitosis were not observed both in Mφ and PGC. It means that they were not tumor cells, but were the reactive cells of the body against the tumor. Based on this view, it would become easy to understand that Mφ and PGC existed always in any lesions of bone, moreover, significant difference of the numbers of Mφ between various bony lesions was shown statistically. The Mφ in grade Igiant cell tumor of bone was more numerous than that in grade 2. The macrophage-like stroma cells in giant cell tumor of bone were likely to be the M which infiltrated to the tumor lesions.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
1990年第2期94-96,共3页
Chinese Journal of Cancer
