摘要
目的对红树植物卤蕨(Acrostichum aureurm)的化学成分进行研究。方法用多种色谱技术对化合物进行分离纯化,并根据化合物的理化性质及波谱数据鉴定化合物的结构。经MTT法进行体外抗肿瘤活性测试。结果从卤蕨乙醇提取物中分离得到6个化合物,分别鉴定为ponasterone A(1)、pterosterone(2)、山奈酚(3)、槲皮素(4)、4-(3,4-二羟基苯基)-2-丁酮(5)、胡萝卜苷(6)。结论6个化合物均为首次从该植物中分离得到。初步的药理试验表明6个化合物对小鼠B16细胞均无生长抑制活性。
Aim To study the chemical constituents of Acrostichum aureurm. Methods The constituents were isolated and purified by column chromatography, and their structures were identified by physicochemical data and spectral data. Results Six compounds were isolated from the ethanol extracts of Acrostichurn aureurm, and their structures were elucidated as ponasterone A（1）, pterosterone（2）, kaempferol（3）, quercetin （4）, 4- （3, 4-dihydroxyphenyl）-2-butanone （5）, and daucosterol （6）, respectively. Conclusion All the com- pounds are isolated from this plant for the first time, and show no growth inhibitory activity on murine melanoma B16 cells by MTT assay.
出处
《中国药物化学杂志》
CAS
CSCD
2006年第1期46-48,64,共4页
Chinese Journal of Medicinal Chemistry
基金
中国热带农业科学院科技基金(RKY0421)
海南省自然科学基金项目(20502)
关键词
药物化学
结构鉴定
柱色谱法
卤蕨
化学成分
medicinal chemistry
structural identification
column chromatography
Acrostichum aureurm
chemical constituents
