摘要
目的观察醛固酮在心肌细胞肥大和心肌纤维化中的不同作用。方法用感觉神经损伤性盐敏感性高血压大鼠模型,哺乳期(三周龄)后分为4组对照+正常(含0.5%氯化钠)饮食(CON+NS)组;辣椒辣素+正常饮食(CAP+NS)组;辣椒辣素+高盐饮食(4%氯化钠)(CAP+HS)组;辣椒辣素+高盐饮食+螺内酯(80mg·kg-1·d-1)(CAP+HS+S)组。干预四个月,比较大鼠血压、血清透明质酸和血清Ⅲ型前胶原浓度、左心室重量体重比,以及心肌病理形态学改变及心功能等。结果螺内酯干预组鼠尾收缩压、血清透明质酸和Ⅲ型前胶原浓度、左室收缩峰压与舒张末压较高血压模型组降低,螺内酯干预组心肌间质胶原成分有减少。螺内酯干预组与高血压模型组大鼠左心室重量体重比、心肌细胞短径、等容舒张期室内压下降的时间常数(T值)无显著性差异,均较正常对照组明显增加。结论醛固酮参与了高盐所致高血压的产生和心肌间质纤维化的过程,但不参与高盐致心肌细胞肥大的过程。
AIM： To observe the different role of aldosterone in cardiac hypertrophy and cardiac fibrosis. METHODS： The salt-Sensitive hypertensive rats induced by sensory denervation by injecting capsaicin were used to study the cardiac remodeling. The rats were divided into 4 groups and subject to the following treatment for 4 months ： Control ＋ normal salt diet （0.5 % Nacl） （ CON ＋ NS） ; capsaicin ＋ normal salt diet（ CAP ＋ NS） ; capsaicin ＋ high salt diet （4% Nacl） （CAP ＋ HS） ; capsaicin ＋ high salt diet ＋ Spironolactone （CAP ＋ HS ＋ S, 80 mg·kg^-1·d^-1 ）. Tail-cuff systolic blood pressure and body weight were measured statedly. At the end of experiment, left ventricular weight index, cardiac muscle pathology morphology, invasive cardiac function and serum concentration of hyaluronic acid （HA） and procollagen type Ⅲ （PC Ⅲ ） were examined. RESULTS： Tail-cuff systolic blood pressure, serum concentration of HA and Pcm, LVSP and LVEDP were lower in CAP ＋ HS ＋ S group than in CAP ＋ HS group. There were no marked differences in left ventricular weight index, myocyte short diameter and isovolumetric relaxation period Time constant （T value） between the two groups, but significantly higher than controls. It was seen that cardiac muscle fibrillar collagen was lessen in CAP ＋ HS ＋ S group. CONCLUSION： Aldosterone is involved in the development of hypertension and the process of cardiac induce by high salt intake, but it is not involved in the process of cardiac hypertrophy which also induce by high salt intake.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2005年第12期1397-1402,共6页
Chinese Journal of Clinical Pharmacology and Therapeutics
基金
广东省自然科学基金项目(№022286)
广州市属高校科技计划项目(№1043)
广州市卫生局项目(№2005YB203)资助
关键词
钠盐
心脏重构
高血压
醛固酮
螺内酯
sodium
cardiac remodeling
hypertension
aldosterone
spironolactone
