摘要
目的通过计算患者体重指数及C肽水平的测定,研究不同肥胖程度对2型糖尿病胰岛β细胞功能的影响。方法将144例2型糖尿病病人按照WHO对亚太地区的肥胖分级标准以体重指数(BMI)<23;23～25;≥25分为A、B、C3组,并通过C肽释放实验测定C肽水平,对3组间年龄、病程等一般情况做单因素方差分析,对3组间C肽水平的比较行重复测量资料的多因素方差分析。结果3组间一般情况无差异,而C肽值存在显著差异,C肽各时间点之间存在显著差异。结论BMI对C肽水平有影响,随着肥胖程度的增加,β细胞分泌能力加强,负担加重,β细胞功能受损,减轻体重有利于控制病情。
【Objective】 To study the impact of different obese grades to the function of pancreatic β cells in type 2 diabetes by calculating their body mass index（BMI） and detecting the level of C peptide. 【Methods】 144 T2DM patients were divided into A, B, C 3 groups according to their body mass index BMI〈23; 23～25; ≥25）. The C peptide were detected by C peptidc releasing test. The basal and biomedical parameters （age, course of disease, HbAlc, et al） among 3 groups were analyzed by one-way ANOVA（analysis of variance） （P 〈 0.05）. The C peptide level among 3 groups was analyzed by repeated measures ANOVA. 【Results】 There arc no differences of the basal and biomedical parametelz among 3 groups（P 〈 0.05）. The C peptide level in group B and C proportionally and significandy rises than that of group A （P 〈 0.01）. In addition, the C peptide levels of 30 min, 60 min, 120 min, 180 min were proportionally and significantly higher than that of 0 min （P 〈 0.01）. 【Conclusions】 BMI impacted the level of C peptide. With the ascending of obese grades, β-cell secretory capacity were strengthened and the burden of β cells were heavier. And then the failure of β cell function were manifested. Losing weight was beneficial to the health of T2DM patients with obesity.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2006年第2期250-252,共3页
China Journal of Modern Medicine
