摘要
观察免疫吸附清除循环肿瘤坏死因子对内毒素休克的治疗作用。方法利用新西兰白兔内毒素休克模型，研究经抗ＴＮＦ单克隆抗体亲和免疫吸附柱血液灌流对血压、肝、肾功能及成活率的影响。结果免疫吸附治疗后血浆ＴＮＦ水平迅速降低，动物血压及肝、肾功能显著改善，早期成活率明显提高。
bjectiveToevaluatetheprotectiveefectofremovalofcirculatingTNFbyimmunoadsorptiononendotoxinshock.MethodsTheNewZealandwhiterabbitsunderwenthemoperfusionthroughtheimmunoadsorbentcolumnsagainstTNF.Thearoticpressureweremeasured,plasmalevelsofTNFandALT,AST,BUN,Crweredetectedandfinalythesurvivalratewasobserved.ResultsPlasmalevelsofTNFsharplyreducedafterim-munoadsorptiontreatment,andsignificantincreaseofaroticpressure,andimprovementoffunctionsofliverandre-nalwereobserved.Moreover,survivalratewassignificantlyhigherthanthatofthecontrolgroup.ConclusionSpecificimmunoadsorptionofcirculatingTNFmightbeanewandefectivetherapyofendotoxinshock.
出处
《中华肾脏病杂志》
CAS
CSCD
北大核心
1996年第5期289-291,共3页
Chinese Journal of Nephrology
基金
国家自然科学基金
