摘要
作者采用免疫组织化学方法对４０例宫颈癌、１０例宫颈慢性炎症和１０例大致正常宫颈组织进行Ｐ－糖蛋白表达测定。结果显示：宫颈癌组织中Ｐ－糖蛋白表达阳性率为４０．０％。而宫颈慢性炎症和大致正常宫颈组织则无一例表达阳性。在宫颈癌中，临床Ⅲ－Ⅳ期、低分化和复发病人癌组织中Ｐ－糖蛋白表达阳性率明显增高（分别为４６．２％，５２．４％和８５．７％）。但癌组织中Ｐ－糖蛋白表达与其组织病理学类型无关。提示Ｐ－糖蛋白表达的检测对宫颈癌疗效及预后的判断有一定价值。
The expression of P-glycoprotein was investigated by immunohistocbemical method in 40 cases of cervical cancer,10 cases of chronic cervicitis and l0 cases of approximately normal control.The results showed that the positive rate of the expression of p-glycoprotein in cervical cancer was 40.0%,while there was no expression of it in the chronic cervicitis and approximately normal control.In cervical cancer, clinical stage Ⅲ￣Ⅳ, 52.4% low-differentiation and relapsed patients had higher expression of p-glycoprotein (46.2%, 52.4% and 85.75,respectively).No significant correlation between expression of P-glycoprotein and pathological type was found.It was suggested that the detection of expression of p-glycoprotein in the tissues of tumor could predict prognosis of the patient with cervical cencer
出处
《实用癌症杂志》
1996年第3期162-164,共3页
The Practical Journal of Cancer
关键词
子宫颈癌
多药耐药
P
糖蛋白
表达
Cervical cancer Multidrug resistance p-glycoprotein
