摘要
背景:黄芪作为传统的中药,具有抗自由基、增加机体免疫力、改善微循环、保护血管内皮细胞及保护神经系统等多种作用。其中,黄芪的神经血管保护作用与其对局部脑皮质血流速度的调节有关。目的:观察脑创伤后黄芪对局部脑皮质血流速度变化的影响。设计:随机配对设计。单位:解放军兰州军区神经外科研究所。材料:实验于 2000-02/05在兰州军区神经外科研究所外伤实验室进行。取健康雄性 SD 大鼠 75只,随机分成正常对照组 5只、盐水对照组和黄芪组各 35只,后两组又分为创伤后 1,3,6,8,12,24和 48h 等 7个时间点,每个时间点 5只动物。方法:正常对照组不造模,其他 2组采用改进的 Feeney’s方法建立颅脑创伤模型;伤后黄芪组立即腹腔注射黄芪注射液(5g/kg),盐水对照组腹腔注射 0.5m L 生理盐水。主要观察指标:测定创伤后相应时间点大鼠脑组织局部脑皮质血流速度。正常对照组打开骨窗后直接测量。结果:经补充后 75只大鼠进入结果分析。局部脑皮质血流速度:盐水对照组伤后 1h 即低于对照组[(6.90±0.68),(7.94±0.65),P <0.05],伤后24h 降至最低点,伤后 48h 开始回升[(5.86±0.61),(6.15±0.60)]。黄芪组各时间点均高于盐水对照组(P <0.05)。结论:黄芪具有明显增加局部脑皮质血流速度的作用,其作用与黄芪的神经血管保护作用有关。
BACKGROUND： Being a traditional Chinese herb, huangqi （astragalus membranaceus） resists free radical, enhances immunity, promotes microcir-culation and protects vascular endothelial cell and nervous system; of which, the protection Of huangqi （astragalus membranaceus） on nervous vessel is related to its regulation on local cerebral cortical blood flow rate.
OBJECTIVE： To observe the effects of huangqi （astragalus membranaceus） on local cerebral cortical blood flow rate after traumatic injury.
DESIGN： Randomized paired experiment.
SETTING： Neurological Surgical Institute of Lanzhou Military Area Command of Chinese PLA. MATERIALS： The experiment was performed in Traumatic Experimental Room of Neurological Surgical Institute of Lanzhou Military Area Command of Chinese PLA from February to May 2000, in which, 75 healthy male SD rats were employed dnd randomized into the control （5 rats）, saline control （35 rats） and experimental group （35 rats）. The latter two groups were subdivided into 7 time spots of 1, 3, 6, 8, 12, 24 and 48 hours after traumatic injury, 5 rats were involved in each spot.
METHODS： In normal control, the model was not prepared and in the other two groups, the modified Feeney＇s method was used to establish craniocerebral traumatic model. In experimental group, right after injury, huangqi injection （5 g/kg） was applied abdominally and in saline control, physiological saline 0.5 mL was injected abdominally.
MAIN OUTCOME MEASURES： It was to determine the blood flow rates in local cerebral cortex at corresponding time spots after traumatic injury. Fenestration was done in normal control for direct determination.
RESULTS： By supplemented, 75 rats entered result analysis. Blood flow rates in local cerebral cortex： the rate in saline control 1 hour after trauma was lower than the control [（6.90±0.68）, （7.94±0.65）, P 〈 0.05], it was decreased to the minimum in 24 hours and began increasing in 48 hours [（5.86±0.61）, （6.15±0.60）]; the rate in experimental group at every time spot was higher than saline control （P 〈 0.05）.
CONCLUSION： Huangqi （astragalus membranaceus） increases remarkably blood flow rate in local cerebral cortex, which is associated with its neurovascular protection.
出处
《中国临床康复》
CSCD
北大核心
2006年第3期172-173,共2页
Chinese Journal of Clinical Rehabilitation
基金
兰州军区医药卫生科研计划项目(LXH 99-08)~~
