摘要
The thermodynamic partitioning behavior of solutes into immobilized artificial membrane(IAM) and n-octanol/water systems was investigated, including acidic,basic,and amphoteric substances.In an n-octanol/buffer system,partitioning process was entropy-dominated for the most studied drugs,while partitioning of oxolinic and nalidixic acids into n-octanol phase was enthalpy-driven.In IAM chromatography,partitioning into membrane for the studied solutes was enthalpy-driven and an exothermal process.In conclusion,there is a significant difference of solutes′ partitioning mechanism into either IAM or an n-octanol phase,therefore,presenting the theoretical basis for differing lipophilicity measuring scale.
The thermodynamic partitioning behavior of solutes into immobilized artificial membrane（IAM） and n-octanol/water systems was investigated, including acidic, basic, and amphoteric substances. In an n-octanol/buffer system, partitioning process was entropy-dominated for the most studied drugs, while partitioning of oxolinic and nalidixic acids into n-octanol phase was enthalpy-driven. In IAM chromatography, partitioning into membrane for the studied solutes was enthalpy-driven and an exothermal process. In conclusion, there is a significant difference of solutes＇ partitioning mechanism into either IAM or an n-octanol phase, therefore, presenting the theoretical basis for differing lipophilicity measuring scale.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2006年第2期349-351,共3页
Chemical Journal of Chinese Universities
基金
国家自然科学基金(批准号:30400563)资助
关键词
热力学分配行为
磷脂膜色谱
正辛醇/水
膜作用
Thermodynamic partitioning behavior
IAM chromatography
n-Octanol/water system
Membrane interactions
