摘要
目的了解β受体阻滞剂治疗围生期心肌病的临床效果。方法将符合诊断标准的25例住院的围生期心肌病患者采取随机、对照的原则分为两组。常规组10例给予地高辛0．125～0．250mg／d，间断使用双氢克尿噻25mg，1～3次／d；安体舒通20mg，1次／d；扩血管药物卡托普利12．5mg，1、2次／d。实验组15例在对照组用药基础上加β受体阻滞剂（美托洛尔，卡维地洛或比索洛尔），关托洛尔开始剂量6．25mg，1次／d；或卡维地洛6．25mg，1次／d；适应后加量至12．5mg，1、2次／d，或比索洛尔2．5mg，1次／d，维持4周。在治疗前后分别测量两组的皇心室射血分数（LVEF）、心功能并统计住院时间，对两组的LVEF变化值、心功能改善程度和住院时间进行比较。结果两组患者的年龄及治疗前心功能、LVEF无明显差异（P〉0．05）；治疗后实验组LVEF明显改善（P〈0．05），心功能改善（P〈0．05），住院时间缩短（P〈0．05）。结论β受体阻滞剂治疗围生期心肌病是安全的，可提高LVEF，有效改善心功能、缩短住院时间、提高生活质量。
Objective To investigate the elinieal effeet of β-blockers therapy in peripartum eardiomyopathy （ PPCM ）. Methods In the random and euntrol study 25 PPCM eases were divided into two groups. 10 eases in mufine group were given 0. 125-0.250 mg/d Digoxin and intermittently given 25 mg DHCT, 1-3 times a day ,20 mg Antisterone,onee a day and 12.5 mg eapotral once or twiee a day. 15 eases in experiment group were given β-blocker （ betaloe, eavidilol or bisoprolol） on the basis of the same administration of medieine with the routine group. The initial dosage of betaloe or eavidilol was 6.25mg,unee a day. After the patients adapted to the medleine the dosage was added to 12.5mg,onee or twiee a day or 2.5mg blsoprolol once a day for 4 weeks. Left ventrieular ejeetion fraetion （LVEF） ,eardiae function and hospitalization time were compared in the two groups before and after treatment. Results There were no differenees in age, pretreatment eardiae funetion and LVEF between groups （ P 〉 0.05 ） eompared with the routine group. LVEF and eardiae function in the experiment group were signhqeantly improved after treatment （ P 〈 0.05 for each ） , and the hospitalization time was shortened （ P 〈 0.05 ）. Conclusion B-blocker for the treatment of peripartum eardiomyopathy is safe may elevate LVEF,effeetively improve the eardiae function,shorten hospitalization time and improve life quality.
出处
《中国综合临床》
北大核心
2006年第2期111-113,共3页
Clinical Medicine of China
