摘要
目的研究支气管哮喘与COPD气道反应性特征,为临床提供参考。方法选择①39例非吸烟健康组(男19例、女20例),(36.51±2.06)岁;②80例哮喘组(男35例,女45例),年龄(40.66±1.43)岁;③39例轻度缓解期COPD组(男21例,女18例),年龄(46.17±2.00)岁。应用日产AstographTCK-6000CV气道反应性测定仪,即强迫振荡方法连续描计呼吸阻力,直接记载累积激动剂量法。应用剂量反应曲线,应用最小累积量(Dmin)或最小浓度即阈值(Cmin)作为气道敏感性指标;气道阻力上升斜率(Sd)作为气道反应性指标。研究哮喘与COPD气道反应性特征。结果哮喘组Dmin为(1.65±0.37)unit,Cmin为(1.13±0.21)mg/ml,显著高于COPD组。哮喘与COPD气道反应性增高,哮喘呼吸阻力上升斜率显著高于COPD,[哮喘组Sd=(9.1±1.99)cm/(H2O·L·sec·unit),COPD组Sd=(1.98±0.63)cm/(H2O·L·sec·unit)]。结论哮喘患者气道敏感性和反应性较高,剂量反应曲线呈等腰三角形,而COPD波形则较低平。在临床实践应用中,结合剂量反应曲线的特点和Dmin/Cmin和Sd评价哮喘和COPD气道反应性的特征值得借鉴和参考。
Objective To determine the characteristics of airway hyperresponsiveness in asthma and COPD. Methods 39 normal subjects, nonsmoker, 80 patients with asthma and 39 COPD were selected. We used the astograph which can directly write the dose-response curve of respiratory resistance （Rrs） by the forced oscillation method during the continuous inhalation of methacholine in stepwise incremental concentrations. Results The mean values of Dmin as indicator for bronchial sensitivity in normal subjects, COPD and asthma were significantly different, P 〈 0. 001. Thus, the bronchial sensitivity in asthma was higher than COPD. In asthmatic patients Sd showing the extent of respiratory resistance was higher than that of the patients with COPD, while there were also significantly differences of Sd between patients with COPD（ 1.96 ±0.63） and normal subjects （0.20 ±0.04）, P 〈0.01. Conclusions The hyperresponsiveness including the bronchial sensitivity and bronchial reactivity , is higher in asthma than in COPD.
出处
《中国医刊》
CAS
2006年第1期36-37,共2页
Chinese Journal of Medicine
