摘要
目的研究2型糖尿病及胰岛素抵抗患者白细胞介素6(IL-6)、白细胞介素8(IL-8)及肿瘤坏死因子α(TNF-α)的变化,分析细胞因子与糖尿病及胰岛素抵抗的相关性。方法采用酶联免疫吸附法测定90例2型糖尿病患者及30例正常人血清各细胞因子浓度,并同时测定空腹血糖(FPG)、糖化血红蛋白、空腹胰岛素(FINS)及空腹C肽(FCP)水平,分析其与细胞因子的相关性。结果与正常对照组比较2型糖尿病组血清细胞因子的含量均明显增高(P<0.01、P<0.05);胰岛素抵抗组的IL-6、TNF-α升高与非胰岛素抵抗组比较差异有统计学意义(P<0.05),胰岛素抵抗与细胞因子的增高密切相关。结论2型糖尿病患者存在着细胞因子的过度激活,并与胰岛素抵抗密切相关,细胞因子在2型糖尿病及胰岛素抵抗的发生发展中起着重要的作用。
Objective To study on the changes of the IL- 6,IL- 8,TNF-α in the type 2 diabetes with insulin resistance and the relation of plasma glucose or insulin resistance and cytokines. Methods （1） To assay the serum level of cytokines in 90 cases with type 2 diabetes meUitns （T2DM） and 30 normal oontrols. （2）To measure the level of fasting plasma glucose （FPG）, hemoglohin A1 c （HBA1 c）, fasting insulin（FINS）, fasting C- peptide （FCP）. （3） To analysis the relation of the level of FPG, HBA1 c, FINS,FCP and cytokines. Results （1） The serum levels of cytokines in T2DM group were significantly increase than in oontrol groups, IL - 6 and TNF- a in T2DM group with inulin resistance were significantly increase than in T2DM group without insulin resistance （2） There was signifi- candy positively oorrelated between insulin resistance and the increasing of cytokine levels. Conclusion There is an excess activation of cytokines in T2DM,which is significantly oorrelated with insulin resistance. Cytokines play the important role in the occurrence and development of T2DM and insulin resistance.
出处
《中国医师进修杂志（内科版）》
2006年第1期42-44,共3页
Chinese Journal of Postgraduates of Medicine
基金
上海市科委科技基金资助项目(012B14046)
