摘要
胰岛移植是治疗糖尿病行之有效的方法,但供体数量不足限制了它的广泛应用,干细胞具有不断增殖和分化的潜能而成为胰岛细胞来源的研究热点。胚胎干细胞和骨髓、胰腺、肝脏等来源的成体干细胞在体外可诱导分化为胰岛内分泌细胞。未来研究应致力于如何提高干细胞诱导分化的效率和改善分化所得胰岛细胞的成熟度。
Islet transplantation is an effective method for diabetes. But extensive application of the transplatation are limited due to deficiency of donor ialet cells. Stem cells have great potentialities of the continuous proliferation and differentiation, and thus, it is thought to he a valuable source for generation of islets in vitro. Embryonic stem cells and adult stem cells derived from pancreas, bone marrow, and liver can he induced and transdifferentiated toward pancreatic endocrine cells under certain conditions, Future studies have to the efficiency of transdifferentiation and produce better functional pancreatic endocrine cells.
出处
《医学综述》
2006年第1期29-31,共3页
Medical Recapitulate
基金
国家重大基础研究前期研究项目(2004CCA01500)
广东省自然科学基金重点项目(037415)
关键词
糖尿病
细胞治疗
胰腺干细胞
Diabetes
Cell therapy
Pancreatic stem cells
