摘要
骨髓间充质干细胞是一群存在于骨髓中的非造血干细胞,具有较强的自我更新能力和多向分化潜能,在体外不同的诱导条件下可分化为骨细胞、软骨细胞、肌腱细胞、脂肪细胞、神经细胞、平滑肌细胞等多种细胞。骨髓间充质干细胞的应用是目前国际上神经系统疾病领域中重要的研究内容,具有广泛的临床应用前景。近年来,许多实验室从分子、生化、物理等水平对其向神经细胞分化调控进行了深入研究,取得了较大的进展。
Bone marrow-derived mesenchymal stem cells （MSCs） are a group of non-hcmatopaietie stem cells residing in bone marrow,which have good self-renewal and multi-differentiate capacity. MSCs can be differentiated a variety of connective tissue cells in vitro such as osteocytes,chondroeytes, tenocytes, edipocytes, nerve cells and smooth muscle cells etc,under distinct induced eonditions. The application of MSCs has been the important subject of investigation in the fields of nerve system diseases internationally,and MSCs have good prospect in clinical use. In recent years, profound studies on the regulation of the differentiation process of MSCs to nerve cells have been performed in molecular,biochemical,physical levels and have made considerable progress.
出处
《医学综述》
2006年第1期5-8,共4页
Medical Recapitulate
基金
兰州军区医学科研基金资助项目(LXH-2005013)
关键词
间充质干细胞
骨髓
细胞分化
组织工程
Mesenchymal stem cell
Bone marrow
Cell differentiation
Tissue engineering
