摘要
目的探讨氟西汀联合心理干预对帕金森病患者情绪障碍的疗效。方法将符合CCMD-3抑郁症诊断标准的帕金森病50例患者随机分成两组。研究组在抗帕金森病药物基础上联合氟西汀20mg/d和心理干预治疗,对照组仅用抗帕金森病药物治疗,疗程8周。采用汉密顿抑郁量表(HAMD)评定疗效。结果经8周治疗后,研究组显效率为80.0,对照组为32.0,两组之间有显著性差异(P<0.01),研究组比对照组抑郁评分下降显著(P<0.05),两组间HAMD减分率于第2、4、8周末比较均有显著性差异(P<0.05～0.01)。结论氟西汀联合心理干预对帕金森病患者情绪障碍具有良好疗效,而且副反应没有明显增加。
Objective To observe the effects of Fluoxetine combined with mental intervention on the emotional disturbance in the patients with Parkinson＇s disease （PD）. Methods 50 PD patients who conform to depression diagnoise standard of CCMD-3 were randomly divided into research group （anti-Parkinson drug combined with Fluoxetine 20mg/d and mental intervention） and control group （single anti-Parkinson drug） for 8 weeks. Clinical curative effects were assessed with the Hamilton Depression Scale （HAMD）. Results At the end of 8th week, the effectual rates of research and control groups were 80.0% and 32.0% respectively, there were significant differences between the two groups （P〈0. 01）, compared with control group, scores of the HANID of the research group significantly decreased （P〈0.05）, at the end of the 2nd, 4th and 8th week of treatment, there were significant difference in score-reducing rates between the two groups （P〈0.05-0.01）. Conclusion Fluoxetine combined with mental intervention has ideal effects on the emotional disturbance in the patients with Parkinson＇s disease and doesn＇t increase side effects.
出处
《中国健康心理学杂志》
2006年第1期43-44,共2页
China Journal of Health Psychology
关键词
氟西汀
心理干预
帕金森病
情绪障碍
Fluoxetine
Mental intervention
Parkinson＇s disease
Emotional disturbance
