摘要
本实验观察生脉注射液对豚鼠Ouabain LD_(100)、致室性纤维颤动、室性心动过速剂量的影响。预先给生脉注射液0.1ml/100g体重Ⅳ(相当于生药0.0415g),5分钟后静脉恒速灌注0.025％Ouabajn,测得Ouabain LD_(100)剂量为0.4mg/kg体重(P<0.01),致室颤剂量为0.29mg/kg体重(P<0.01),致室性心动过速剂量为0.28mg/kg体重(P<0.01)。预先给单方五味子和人参根提取液各为20mg/100g体重(生药)Ⅳ,其Ouabain LD_(100)为0.43mg/kg(P<0.01)和0.34mg/kg(P<0.05)。生脉注射液、五味子提取液、人参根提取液对豚鼠Ouabain LD_(100)剂量都有增加作用,与对照组比较有非常显著和显著意义。生脉注射液还增加Ouabain致室颤和室性心动过速剂量,与对照组比较有非常显著的意义。结果提示,生脉注射液对强心甙的心脏毒性有保护作用。
The expriment was carried out with the injectio Sheng-Mai into guinea pigs. It was given beforehand by Ⅳ that injectio Sheng-Mai 0.1ml/100g (equivalent to 0.0415g galenic pharmacy), Sceisandra Chinensis 20mg/100g (galenic pharmacy) and panax ginseng C. A. Mey 20mg/100g (galenic pharmacy) and 5 minutes late the estimation of LD 100 of ouabain was 0.4mg/kg (P<0.01), 0.43/kg (P<0.01) and 0.34mg/kg (P<0.05). The dosages of ouabain on ventricular tachycardia and ventricular fibrillation were singnificantly increased to 0.28mg/kg (P<0.01) and to 0.29mg/kg (P<0.01) respectivily by the injectio Sheng-Mai. The results showed that injectio Sheng-Mai have protective effect on digitalis intoxication in guinea pig.
出处
《暨南大学学报（自然科学与医学版）》
CAS
CSCD
1989年第4期17-20,共4页
Journal of Jinan University(Natural Science & Medicine Edition)
