摘要
目的:观察狂犬病暴露后接种狂犬疫苗对机体的细胞免疫作用。方法:狂犬病暴露者接种狂犬病疫苗后,检测狂犬病毒抗体的同时,运用淋巴细胞转化试验检测自发淋巴细胞转化率和狂犬病疫苗剌激后的狂犬病毒淋巴细胞转化率,以后者减前者计算出狂犬病毒特异性淋巴细胞转化率。结果:狂犬病疫苗接种后,抗体效价达到>1∶5的100例中,76例同时产生细胞免疫力(即狂犬病毒特异性淋巴细胞转化率>5%);而抗体效价等于1∶5的4例和未产生抗体的35例中,均未产生细胞免疫力。结论:狂犬病暴露者接种狂犬病疫苗后,并非都能同时产生体液和细胞免疫力,不能产生细胞免疫力者,其总体细胞免疫功能亦偏低。
Objective：To investigate the cellular immune effect of rabies vaccine of the persons exposed to rabies. Methods： Persons who were exposed to rabies and vaccianated with rabies vaccine. While the rabies antibody in the blood from the above persons was examined, the lymphocyte transformation test was used to detect the spontaneous PLT（ percent of lymphocyte transformation） ,and PLT of rabies vaccine which was inspired. Results：Of 100 persons whose blood antibody titer was 〉 1： 5, only 76 persons had the cellular immunity effect （ the particular PLT was 〉 5%. Of 35 persons who had no antibody and 4 persons whose blood antibody titer was 1 ： 5, no one had the cellular immune effect. Conclusion： Not all the persons exposed to rabies and vaccinated rabies vaccine can acguire the antibody and cellular immunity simutaneously. On the whole, the persons who could not engender the particular cellular immunity to rabies, bad slightly lower cellular immunity than those who could engender the particular eellular immunity to rabies.
出处
《南通大学学报（医学版）》
2006年第1期28-30,共3页
Journal of Nantong University(Medical sciences)
关键词
狂犬病
疫苗
抗体
细胞免疫
淋巴细胞转化率
Rabies
Vaccine
Antibody
Cellular immune
Percent of lymphocyte transformation（PLT）
