摘要
目的观察氟达拉滨联合环磷酰胺化疗方隶对晚期淋巴系统恶性肿瘤的疗效、观察骨髓抑制时间及不良反应。方法FLU30mg／m^2·d^-1×4-5d，CTX400mg／m^2·d^-1×2d。定期复查血象，当WBC≤1×10^9／L时开始用G—CSF5μg／kg·d^-1直至WBC≥4×10^9／L。结果治疗的4例晚期淋巴系统恶性肿瘤病人，其中有2例部分缓解。中性粒细胞计数最低时间在开始用药后4—12d，持续时间10—54d。血小板计数最低时间在开始用药后7—12d，持续时间10—56d。不良反应主要是轻度的恶心、呕吐。结论氟达拉滨联合环磷酰胺化疗方案对晚期慢淋有效，对复发的高度恶性淋巴瘤疗效不佳。
Objective To investigate the therapeutic effects of Fludarabine combined with CTX for late stage maligant lymphatic system tumors. Methods Fludarabine 30mg/m^2·d^-1 ×4-5day, CTX400mg/m^2·d^-1× 2day were used to treat 4 eases of late stage maligant lymphatic system tumors.when the WBC in the blood ≤1×109^/L ,G- GSF 5μg./kg·d^-1 were used to ineease WBCin the blood ≥4×10^9/L. Results During the the 4 eases, 2eases showed response to the therapy and procured partial relief, neutropeia begin at the time 4 - 12days after the regimen initiating and last 10-54days. the adverse reaction includes nausea and vomiting. Conclusion Chemical therapy of Fludarabine combined with CTX shows good effects for late stage chronoc lymphocytic leukemia shows no effects for relapsing malignant lymphoma.
出处
《中国热带医学》
CAS
2006年第1期97-98,共2页
China Tropical Medicine
关键词
氟达拉滨
环磷酰胺
淋巴系统
恶性肿瘤
Fludarabine
Cyclohosphamide
Lymphatic system
malignant tumors
