摘要
目的：观察米非司酮治疗围绝经期功能性子宫出血的临床疗效。方法：80例确诊为围绝经期功能性子官出血患者·口服米非司酮12．5mg，连服6个月，观察子宫大小、内膜厚度、月经恢复情况及血清激素水平。结果t所有患者用药期问均闭经，其中33例直接进入绝经期，其余停药后28～70d，平均42d恢复月经。15例月经稀发、量少。用药前子官内膜（5．8±0．2）mm与用药后（2．7±0．3）mm比较有显著性差异（P〈0．05）；用药前后子宫大小无明显差异（P〉0．05）。治疗6个月后血清激素检查显示促卵泡生成索（FSH）、黄体生成索（LH）、孕激素（P），雌二醇（E2）水平均有明显降低。结论：米非司酮可有效抑制子宫内膜生长，治疗围绝经期功能性子官出血效果满意．
Objective：To observe the clinical effect of mifepristone on dysfunctional uterine bleeding during peri-menopausal period. Methods.Eighty patients with dysfunctional uterine bleeding during peri-menopausal period took 12. 5 mg mifepristone orally, once a day, for 6 consecutive months,followed by being observed for changes of uterine size, thickness of the endometrium, condition of menstruation and hormone. Results： Menopause occurred in all the patients during treatment,33 of them developed menopause directly and the rest recovered 28-70 days after stopping mifepristone,on an average of 42 days. However 15 patients had scarce and less menstruation. The endometrial thickness became thin from（5.8±0.2）mm to（2.7±0.3）mm after taking mifepristone with a significant difference （P〈0. 05）. There was no remarkable difference in uterine size after the patients took mifephstone （P〉0.05）. FSH,LH,P,E2 reduced in the patients after 6 months. Conclusion： Mifepristone could effectively inhibit the growth of endometrium and treat dysfunctional uterine bleeding during peri-menopausal period,with satisfying result.
出处
《实用临床医学（江西）》
CAS
2006年第1期83-84,共2页
Practical Clinical Medicine
关键词
米非司酮
功能性子宫出血
围绝经期
mifepristone
dysfunctional uterine bleeding
peri-menopausal period
