摘要
目的:探讨人乳头状瘤病毒(HPV16)、单纯疱疹Ⅱ型病毒(HSV-2)与子宫颈病变性质的病因发病学关系。方法:应用免疫组化LSAB法对24例子宫颈湿疣、24例子宫颈上皮内瘤(CIN)和53例子宫颈浸润性鳞癌 (SCC)组织进行HPV16、HSV-2检测。结果:在子宫颈湿疣、CIN、SCC中HPV16检出率分别为62．5％、25．0％、 66．0％;HSV-2检出率分别为83．3％、41．6％、56．6％;HPV16、HSV-2同时检出阳性率分别为54．1％、16．6％及 43．3％。HPV16检出率随CIN、SCC病理分级增高而增加,不同民族的HPV16检出率差异无统计学意义。结论: HPV16感染是子宫颈癌发病的重要因素,且HSV-2在子宫颈鳞癌的发病中具有协同作用。
Objective： To study the relationship between HPV16, HSV-2 infection and human cervical lesions. Methods： Detection of HPV16; HSV-2 in women patients with cervical intraepithelial neoplasia （CIN） 24, condyloma 24, and invasive squamous cell carcinoma （SCC） 53 by immunochemistry were carried out respectively. Results： The detected frequencies of HPV16 were 25.0% （6/24）, 62.5%（15/24） , and 66.0% （35/53） in CIN, condyloma, and SCC respectively; the HSV 2 were 41.6%（10/24） , 83.3%（20/24） and 56.6%（30/53） in CIN, condyloma, and SCC respectively. The frequency of HPV16 was higher in CIN-Ⅲ and SCC than in others. However, no statistic difference of these virogenes infection be tween Uygur and Hans women was found. Conclusions： HPV16 may be a critical etiologic factor for cervi cal carcinogenesis in human beings; HSV 2 as a human papillomavirus cofactor in the etiology of invasive cervical cancer;The frequency of HPV16, HSV-2 in cervical neplastic lesions no statistic difference in Uygur and Hans women in Hami was found.
出处
《新疆医科大学学报》
CAS
2006年第1期67-68,共2页
Journal of Xinjiang Medical University
