摘要
目的探讨乙型肝炎病毒(HBV)阳性孕妇孕期足三里穴位注射乙型肝炎免疫球蛋白(HBIG)预防HBV宫内感染的效果。方法2001年11月至2003年10月烟台毓璜顶医院将190例乙型肝炎表面抗原(HB-sAg)阳性孕妇随机分为两组足三里穴位注射组92例,于孕20、24、28、32、36周足三里穴位注射HBIG共5次,每次200IU。肌肉注射组98例,同剂量、同时间应用HBIG。采用酶联免疫法,检测用药前后孕妇血清及新生儿脐血清HBsAg、HBeAg及HBsAb,采用核酸扩增(PCR)荧光定量检测HBV-DNA含量。结果92例足三里穴位注射者,新生儿HBV宫内感染8例,宫内感染率为8.7%,低于肌肉注射组(P<0.01)。穴位注射组新生儿脐血清HBsAb检出率显著高于肌肉注射组(P<0.05)。穴位注射组临产前血清中HBV-DNA显著低于肌肉注射组(P<0.05)。结论通过孕妇足三里穴位注射HBIG,可更有效地减少HBV的宫内感染,未发现任何副反应。
Objective To study the efficacy and possible mechanism of acupoint injection of hepatitis B immuoglobulin （HBIG） during pregnancy in preventing intrauterine HBV infection. Methods From Nov. 2001 to Oct. 2003,190 cases of pregnant women with both HBsAg positive and HBeAg positive were divided into two groups in Yantai Yuhuangding Hospital. Each case in the acupoint injection group （92 cases） was injected HBIG into acupoint at the 20th ,24th ,28th, 32th,36th week during pregnancy （200IU per time）. Each subject in the intramuscular injection group （98 cases） received 200IU of HBIG intramuscularly （IM） at the same gestation age. Blood samples were taken before and after HBIG injection in all pregnant women, and umbilical blood was taken at birth. HBsAg, HBeAg, Anti-HBs and HBV-DNA load in the blood samples of pregnant women and umbilical blood were tested respectively by using enzyme linked immunosorbant assay （ELISA） and polymerase chain reaction （PCR）. Results The incidence of HBV intrauterine infection was 8.7% （8/92） in the acupoint injection group, The vertical transmission incidence of the newborns was lower in the acupoint injection group than in the intramuscular group （P 〈0.01 ）. The detection rate of anti-HBs of the newborns was significantly higher in the acupoint injection group than in the intramuscular injection group （ P 〈 0.05 ） ; whereas, serum HBV-DNA load was significantly lower before parturience in the acupoint injection group than in the intramuscular injection group （P 〈 0. 05）. Conclusion Acupoint injection of HBIG during pregnancy can effectively reduce the incidence of HBV intrauterine infection without any side effects.
出处
《中国实用妇科与产科杂志》
CAS
CSCD
北大核心
2006年第1期47-48,共2页
Chinese Journal of Practical Gynecology and Obstetrics
关键词
乙型肝炎病毒
妊娠
穴位注射
免疫球蛋白
Hepatitis B virus
Pregnancy
Acupoint injection
Immunoglobulin
