摘要
目的探讨视网膜母细胞瘤自发退行的临床发生发展特点和组织病理学特点，为临床工作中该疾病的诊断和治疗提供参考。方法对31例视网膜母细胞瘤白发退行病例的临床和组织病理学资料进行回顾性分析。结果31例病例平均年龄25．06月，首发症状多为白瞳症（77．19％）、眼红（48．39％）和眼球变小（25．81％），病程为0．5月～4.5年，多出现类似青光服发作、色素膜炎、眼内炎及发热等症状，最终白发退行，组织病理检查可见肿瘤灶内大片坏死、凋亡区及血管退行性改变，部分白发退行病灶中仍可见残存的肿瘤细胞。结论临床工作中应重视眼红、眼球变小等视网膜母细胞瘤的非典型表现，减少误诊；同时对视网膜母细胞瘤自发退行应密切随访观察。
Objective To investigate the clinical characteristics and histopathological features of spontaneously regressed retinoblastoma. Methods The histories of the 31 patients and the datum of pathology of enucleated eyeballs were reviewed retrospectively. Results A total of 31 cases of retinoblastoma with spontaneous regression were included, 77.19 % of the patients had leukocoria, 48.39 % had inflamed eyes, 25.81% had microphthalmos. The patients presented with signs of glaucoma, uveitis or endophthalmitis during the nature course. Histopathology demonstrated extensive necrotic and apoptotic cells appeared in regressive areas, but there were still some active cells among the dying cells. Conclusions The children with any atypical presentations of retinoblastoma should be paid attention to and be followed up closely.
出处
《中国实用眼科杂志》
CSCD
北大核心
2006年第1期75-78,共4页
Chinese Journal of Practical Ophthalmology
关键词
视网膜母细胞瘤
自发退行
病理
Retinoblastoma
Spontaneous regression
Pathology
