摘要
目的:观察在综合治疗基础上,全身或局部使用糖皮质激素对慢性阻塞性肺疾病急性加重期的临床疗效。方法:慢性阻塞性肺疾病急性加重期患者102例,随机分为对照组和治疗1、2组。对照组给予氧疗、抗感染、止咳、祛痰、纠正酸碱平衡等;治疗组在上述治疗基础上加用静脉滴注甲基强的松龙吸入布地奈德粉吸入剂或二丙酸倍氯米松,组间进行疗效观察。结果:甲基强的松龙治疗组和吸入布地奈德混悬液或二丙酸倍氯米松治疗组与对照组比较疗效差异具有显著性,疗效明显;两个治疗组比较,差异无显著性,疗效相同。结论:慢性阻塞性肺疾病急性加重期早期使用糖皮质激素可以缩短恢复时间,加快肺功能改善并降低治疗失败率。
Objectives：To observe the clinical effect of glucocorticostteroid on acute exacerbation of chronic obstructive pulmonary disease based on comprehensive treatment. Methods： One hundred and two cases of acute exacerbation of chronic obstructive pulmonary disease were randomly divided into treatment group 1 ＆ 2 （ n1 = 38, n2 = 34） and control group （ n = 30） .The control group was given antibiotics, oxygen and treatment for expectoration, relieved cough and balanced hydro-elctrolytic. The treatment group was given the therapies mentioned above and methylprednisolone 80mg once a day for 3 days, prednisone 30mg once a day for 10 days, budesonide 400μg twice a day or beclometasone 200μg once every 8 hours. Results： The significant difference was seen between the treatment group and the control group（ P 〈 0.05 ）. The significant difference was not found among the two treatment groups. Conclusions： Gglucocorticostteroid is effective for acute excerbation of chronic obstructive pulmonary disease.
出处
《四川省卫生管理干部学院学报》
2005年第4期250-251,共2页
Journal of Sichuan Continuing Education College of Medical Sciences
关键词
肺疾病
慢性阻塞性
急性加重
糖皮质激素
疗效
Pulmonary disease
Chronic obstructive
Acute exacerbation
Glucocorticostteroid
Effect
