摘要
目的:研究氯沙坦用于治疗慢性充血性心力衰竭的疗效。方法:采用随机对照分组研究,对照组87例给予标准治疗包括利尿剂、ACEI、β受体阻滞剂、阿斯匹林及/或洋地黄等;治疗组88例在此基础上加用氯沙坦片25～50mg/d,总疗程6个月,比较两组临床及心功能改善情况。结果:治疗组总有效率90.91%,对照组总有效率77.01%,两组比较有显著性差异(P<0.05)。治疗前后两组SV及LVEF值均有较大改善,组间比较差异显著(P<0.05)。结论:慢性充血性心力衰竭在综合治疗基础上加用AngⅡ受体拮抗剂氯沙坦,可取得更好的疗效,而副作用并无明显增加。
Objectives：To study effect of Losartan on chronic congestive heart failure. Methods： 175 patients were randomly divided into two groups87 patients were in the control group treated by normal medicine such as diuretic, ACEI,β-receptor inhibitor, aspirin or digitalis88 patients were in the experimental group treated by normal medicine mentioned above plus Losartan 25-50mg/d produced by MSD Pbarmaceutical Co L1d for 6 months. Results： The effective ratios were 90.91% for the experimental group, and 77.01% for the basic group There was obviously difference between the two groups （ P 〈 0. 05 ）SV and I,VEF were improved greatly after treatment in both two groups（ P 〈 0.05 ）.Conclusions： Chronic congestive heart failure can be improved greatly by basic treatment plus Ang Ⅱ-receptor inhibitor Losartan but without obvious side-effects.
出处
《四川省卫生管理干部学院学报》
2005年第4期248-250,共3页
Journal of Sichuan Continuing Education College of Medical Sciences
关键词
氯沙坦
治疗
慢性充血性心力衰竭
Losartan
Treatment
Chronic
congestive heart failure
