摘要
采用单克隆抗体和免疫荧光技术检测２５例骨髓增生异常综合征（ＭＤＳ组）和２０例正常人（对照组）外周血Ｔ淋巴细胞亚群。结果ＭＤＳ组总Ｔ细胞（Ｔ２）百分比和绝对值较对照组均降低（Ｐ＜００１），抑制Ｔ细胞（Ｔ８）百分比和绝对值均增高（Ｐ＜００５），辅助Ｔ细胞（Ｔ４）与Ｔ８比值降低（Ｐ＜００１）而Ｔ４百分比和绝对值无明显差异（Ｐ＞００５），可能与多数患者检测前应用了激素等治疗有关。重度贫血者Ｔ４百分比和Ｔ４／Ｔ８比值较中度贫血者明显降低（Ｐ＜００５），而Ｔ８百分比无明显差异（Ｐ＞００５）。
The peripheral blood lymphocyte subsets were detected by monoclonal antibody with a panel of immunofluroescent technigne in 25 cases with MDS and 20 healthy controls.The results showed that the percentages and absolute value of pan T cells(T 2) of MDS patients were lower than those of healthy controls(P<0 01),but the percentages and absolute value,T suppressor cells(T 8) were higher(P<0 05).Howerve,there were no significant difference in percentages and absolute value of T helper cells(T 4)(P>0 05).This might be related to the using of hormone before test in most patients.There was decrease of T 4/T 8 ratio (P<0 01),while no significant decrease of percentage of T 8 cells in severe anemia patients than in moderate anemia patients (P>0 05).
出处
《中日友好医院学报》
1996年第2期157-159,共3页
Journal of China-Japan Friendship Hospital
关键词
骨髓增生异常
综合征
T淋巴细胞亚群
免疫
myelodysplastic syndrome
T lymphocyte subset
antibodies,monoclonal
