摘要
采用随机双盲对照方法,对尼莫地平与安慰剂治疗46例多灶性梗死性痴呆进行研究.治疗组和对照组各23例,治疗组服尼莫地平80～160mg/d,疗程8周.结果显示,治疗组总有效率为87.0%,对照组为56.5%(P<O.05);治疗组记忆商由69.3±15.7增至85.1±17.4(P<0.O1),对照组由72.5±16.2增至78.3±18.6(P>O.05);尼莫地平不良反应轻微,使用安全.
A double-blind trial of nimodipine in therapy of multi-infarct dementia was conducted on 46 patients, who were equally divided into treated group and control group. The nimodipine dosage was 80-160mg/d, po, for 8wk. The total response rate of treated group was 87. 0%, that of the control (phacebo) group 56. 5% (P<0. 05). The memory quotient of treated group increased from 69. 3±15. 7 to 85.1±17.4(P<0.01), that of the control group increased from 72.5±16.2 to 78.3±18.6(P>0.05). Adverse reactions of nimodipine were mild and so it is safe.
出处
《药物流行病学杂志》
CAS
1996年第2期71-73,共3页
Chinese Journal of Pharmacoepidemiology
