摘要
目的利用组块设计功能核磁共振成像技术研究言语性“熟悉”声音的神经基础。方法利用1.5T核磁共振成像系统对13名中国汉族成年健康男性受试者进行扫描,同时给予事先录制编辑好的言语性声音刺激,并通过反馈系统记录反应结果。应用SPM99软件处理分析数据,获得脑区激活图和局部血氧水平反应曲线,并分析受试者行为学反应结果之间及其与激活脑区之间的相关性。结果与接受“不熟悉”声音刺激相比,受试者在接受“熟悉”声音刺激时,下列脑区显著激活:后扣带回(0,-51,23;104像素)、丘脑(0,-15,4;83像素)、右颞中回(50,-37,2;22像素)和右前额中回(53,15,36;12像素)。相关分析表明,受试者对“熟悉”声音的判断正确率与对“熟悉”声音识别的平均反应时间呈明显负相关;而辨别“熟悉”声音的平均反应时间与丘脑的激活程度呈明显正相关。结论后扣带回、丘脑、右颞中回及右前额中回可能是辨别“熟悉”声音神经网络基础的重要组成部分。
Objective The identify the meural fundation for the recognition of familiar verbal voice by functional magnetic veronance imaging（fMRI）, Methods Thirteen Chinese health male subjects （mean age 26.1 years, SD = 2.9 years） participated in the study. All subjects were right-handed and Han nationality. The sub- jects listened to familiar （subjects＇friends） and unfamiliar voices when functional scanning. Functional data were acquired using a 1.5T MRI （ GE Systems, USA ） , and were analyzed using statistical parametric mapping 99 （SPM99）. A fixed-effects model was employed to assess the difference in BOLD response between familiarity and unfamiliarity conditions（ P 〈 0. 001, uncorrected for multiple comparisons, extent threshold more than 5 voxels）, The behavioral results were recorded by Presentation software. Furthermore, an estimate of the magnitude of the BOLD response with performance on behavior task cross subjects were correlated. Results The posterior cingulate gyms, thalamus, right medial temporal gyms and right medial prefrontal gyms were more activated by familiar task than unfamiliar task. The mean reaction time to familiar voices correlated positively with the activation degree of thalamus when subjects recognized familiar voice. Conclusion The results suggested that the posterior cingulate gyms, thalamus, right medial temporal gyms and right medial prefrontal gyms play very important roles in recognition of familiar verbal voices.
出处
《中国行为医学科学》
CSCD
2006年第1期1-3,共3页
Chinese Journal of Behavioral Medical Science
基金
国家自然科学基金资助项目(30370519)
江苏省六大人才高峰资助项目(D)
南京医科大学校基金资助项目(NY03081)
