摘要
兔脑磷脂(RBP)100～200 mg·kg^(-1)ip或sc,对4种急性渗出性炎症模型均有显著的抗炎作用,卵磷脂和脑磷脂为RBP抗急性炎症的有效成分.但RBP对慢性增生性炎症无抗炎作用.对正常和免疫受抑动物,RBP能增加脾重,提高碳粒廓清率和腹腔巨噬细胞的吞噬指数,提高淋巴细胞转化率和溶血素抗体生成及肝细胞.cGMP含量.在体外,小剂量RBP促进正常人淋巴细胞增殖反应,大剂量呈抑制作用.
Rabbit's brain phospholipids (RBP) 100~200 mg ?kg-1 ip or sc showed anti-inflammatory action on four kind of acute inflammatory animal models. Cephalin and Lecithin were the effective component of antiin-flammatory action on the acute inflammatory animal model. But RBP did not show antiinflam-matory action on the chronic proliferative inflammatory model. RBP increased blood carbon particle clearance, perfaneal macrophage phagocytosis and enhanced lymphocyte proliferation,hemolysin antibody in normal and immunode-pression animal. RBP increased the cGMP content in the liver tissue of immunodepression animal, 0. 1~1 mg ?L-1 RBP promoted proliferation but 100 mg ?L-1 RBP inhibited proliferation induced by PHA in vitro on human lymphocyte.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1996年第2期146-148,共3页
Chinese Pharmacological Bulletin
关键词
兔
脑磷脂
抗炎作用
碳粒廓清率
溶血素抗体
animal phospholipids
antiin-flammatory action
macrophage
carbon particle clearance
hemolysin antibody
lymphocyte pro-liferation
