摘要
大鼠ｉｐ不同剂量的氯胺酮（５０，１００，２００ｍｇ·ｋｇ－１），除小剂量（５０ｍｇ·ｋｇ－１）兴奋大脑皮质Ｎａ＋．Ｋ＋－ＡＴＰ酶活性外，其余剂量对鼠脑４个分区的酶活性均有抑制作用．５０ｍｇ·ｋｇ－１氯胺酮显著抑制海马Ｎａ＋，Ｋ＋－ＡＴＰ酶，１００ｍｇ·ｋｇ－１显著抑制大脑皮质、纹状体和海马Ｎａ＋，Ｋ＋－ＡＴＰ酶；２００ｍｇ·ｋｇ－１显著抑制脑干和海马Ｎａ＋，Ｋ＋－ＡＴＰ酶。结果提示．氯胺酮对中枢神经系统的抑制作用可能与其抑制脑组织中Ｎａ＋，Ｋ＋－ＡＴＰ酶活性有关。
The effects of ketamine at 50,100, 200mg·kg-1(ip)on the activity of Na+,K+-ATP ase in rat cerebral cortex, brain stem,corpus striatum and hippocampus were studied.Except that Na+, K+-ATPase in cerebral cortex was activated by ketamine at 50 mg·kg-1,all other experiment groups of ketamine inhibited Na+, K+-ATPase activity in four different areas of rat brain. Ketamine at 50 mg· kg-1 significantly inhibited Na+, K+-ATPase in hippocampus, at 100 mg·kg-1Na+,K+-ATPase in cerebral cortex and corpus striatum and at 200 mg·kg-1Na+, K+-ATPase activity in brain stem and hippocampus. The results indicated that the inhibitory effect. of ketamine on the central nervons system are associated with its inhibition on Na+, K+-ATPase activity in the brain.
出处
《中国药理学通报》
CSCD
北大核心
1996年第3期249-251,共3页
Chinese Pharmacological Bulletin
