摘要
为调查卡托普利（Ｃａｐ）的特殊血管效应和探讨其机制，用电镜和图象技术观察口服Ｃａｐ对自发性高血压大鼠（ＳＨＲ）主动脉平滑肌细胞（ＡＳＭＣ）超微结构和Ｃａ２＋的影响。用Ｃａｐ治疗ＳＨＲ１６ｗｋ，降低主动脉中膜厚度（１０４．７±６．６μｍｖｓ１３５．７±８．１μｍ）和改善ＡＳＭＣ的异常超微结构征象如异形核、线粒体肿胀和管状结构扩张以及降低ＡＳＭＣＣａ２＋浓度。故Ｃａｐ有阻止ＳＨＲ主动脉中膜肥厚和改善ＳＨＲＡＳＭＣ异常性超微结构的特殊血管效应。而降ＡＳＭＣＣａ２＋可能部分与它的特殊效应有关。
The effect of oral captopril(Cap)on the ultrastructure and intracellular Ca2+([ Ca2+] i)Of aortic Smooth muscle Cells(ASMC)from spontaneously hypertensive rats(SHR)was investigated and its mechanism responsible its particular effect on blood vessel was evaluated by using transmission electron microscope and digital image processing technique.16 wk of treatment with Cap lessened medial thickness of aortae(104.7±6.6 vs 135.7±8.1μm)and abnormal ultrastructural signs of ASMC from SHR including heterogeneous population of nuclei,swelling of mitochondria and tubular systems as Well as decreased [Ca2+] i in ASMC.Cap possesses particular effect on blood vessel in preventing aortic medial thickness and improving of abnormal ultrastucture,which may be in part associated with a fall in [ Ca3+] i in ASMC.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1996年第3期229-232,共4页
Chinese Pharmacological Bulletin
基金
国家自然科学基金
上海市高教局.No93CB30部分资助
关键词
胸主动脉
钙
卡托普利
超微结构
平滑肌细胞
thoracic aorta
cultured cells
inbred WKY rats
inbred SHR rats
fura-2
calcium
captopril
ultrastructure
