摘要
目的探讨重症肌无力(MG)患者胸腺切除后体液免疫变化与临床疗效的关系。方法测定21例胸腺未切除(非手术组)、25例胸腺切除(手术组)MG患者外周血细胞因子(IFN-γI、L-4),乙酰胆碱受体抗体(AChRAb)、免疫球蛋白(IgGI、gMI、gEI、gA)、补体(C3、C4)变化。以性别、年龄相匹配的健康者作对照。结果手术组MG患者IFN-γ水平显著低于非手术组(P<0.01),但仍显著高于对照组(P<0.01)。MG手术组无效者IFN-γ水平显著高于完全缓解和部分缓解者(分别为P<0.01,P<0.05),部分缓解者显著高于完全缓解者(P<0.01)。手术组、非手术组与对照组间IL-4水平差异均无显著性(P>0.05)。MG手术组患者AChRAb显著低于非手术组(P<0.05),但仍显著高于对照组(P<0.05);手术组、非手术组及对照组间,以及手术组不同疗效者间外周血免疫球蛋白、补体水平差异均无显著性(P>0.05)。结论MG患者胸腺切除后体液免疫紊乱可得到一定程度纠正但未完全恢复正常。
Objective To study the relation of humoral immunity and clinical effects following thymectomy m myasthenia gravis （MG） patients. Methods Measure cytokines .IL-4 and IFN-γ, AChR antibodies, immunoglobulins （IgG, IgM, IgE, IgA）, and complements （C3, C4） activities were detected in the peripheral venous blood of MG patients with and without thymectomy. Results The level of IFN-γ in MG patients with thymectomy was significantly higher than that in control subjects （P〈0. 01）, but was significantly lower than that in MG patients without thymeetomy. The level of IFN-y in MG patients with thymeetomy was significantly lower than that in no effect patients （P〈0. 01）, but significantly higher than that in complete remission patients （P〈0. 01）. No significant difference of IL-4 was found between each group. The level of AchR antibodies in MG patients with thymectomy were significantly higher than that in control subjects （P〈0. 01）, but was significantly lower than that in MG patients without thymectomy. The levels of immunoglobulins and complements had no significant difference between each group. Conclusions The disorder of humoral immunity in myasthenia gravis patients recovers partially after thymectomy.
出处
《中国神经免疫学和神经病学杂志》
CAS
2006年第1期5-8,共4页
Chinese Journal of Neuroimmunology and Neurology
