摘要
目的:评价抗病毒药物阿昔洛韦(aciclovir)联合糖皮质激素泼尼松(prednisone)治疗贝尔面瘫的疗效。方法:46例贝尔面瘫病者被随机分成阿昔洛韦联合泼尼松组(A+P组,n=23)和泼尼松治疗组(P组,n=23)。A+P组口服阿昔洛韦每日3次,每次0.4g和泼尼松每日一次,每次50mg,P组口服泼尼松每日一次,每次50mg,连续5d,接着各组均将泼尼松减量为隔日一次,每次20mg。面神经功能指数(facialnerve functional index,FNFI)作为评判疗效指标。结果:治疗后第3周A+P组中有12例(52.1%)面神经完全恢复(FNFI=1),P组为5例(21.7%)两者有显著性差异(P<0.05);而治疗后第4周,A+P组21例(91.3%)和P组18例(78.3%)面神经完全恢复(P>0.05)。结论:阿昔洛韦联合泼尼松治疗贝尔面瘫疗效确切,无明显副作用;疗程比单纯用泼尼松治疗有明显缩短。
PURPOSE： To evaluate the outcome of treatment with an antiviral drug in combination with corticosteroids in patients with Bell＇s palsy. METHODS： 46 patients with Bell＇s palsy were randomly divided into two groups, aciclovir and prednisone group （A＋P group, n=23） and prednisone group （P group, n=23）. The patients in A＋P group were treated with 0.4g of aciclovir tablets 3 times per day for 5 days and 50 mg of prednisone daily for 5 days, and the patients in P group were treated with 50 mg of prednisone daily for 5 days, and then the dosage of prednisone was reduced by 20 mg per two days for the next 10 days. Facial nerve function index （FNFI）was used as a evaluating method of the outcome. RESULTS： 12 patients （52.1%） in the A＋P group recovered completely （FNFI=1）, as compared with 5 patients （21.7%） in the P group （P〈0.05） after treatment three weeks, and 21 patients （91.3%） in the A＋P group comparing with 18 patients （78.3%） in the P group （P〉0.05） after treatment four weeks. CONCLUSIONS： The study showed a significantly better outcome in the patients with Bell＇s palsy treated with aciclovir and predisone as compared with the patient given prednisone treatment without serious complications.
出处
《上海口腔医学》
CAS
CSCD
2005年第6期590-592,共3页
Shanghai Journal of Stomatology
