摘要
应用国产试剂盒对Ⅲ型前胶原肽(PⅡP)、N型胶原肽(N—C)、板层素(LN)和透明质酸(HA)4项血清学标志物作联合检测,比较其在慢性迁延性肝炎(CPH),慢性活动性肝炎(CAH)和肝炎后肝硬化(LC)血清中的水平。结果,CAH患者分别为16.29±3.58U/ml,216.49±100.86ng/ml,196.87±88.45ng/ml,147.55±36.85ng/ml,LC患者分别为21.04±4.74U/ml,385.8±95.76ng/ml,769.29±652.28ng/ml,182.56±44.39ng/ml。与正常人相比均有显著性差异,P值<0.05,LC高于CAH。而CPH除HA外与正常人相比无显著性差异,P值>0.05。与国内文献报道相似。4项指标与ALT增高无相关性,与血清蛋白电泳中γ球蛋白增高有显著相关性。联合检测有功于LC的诊断及疗效观察。
The levels of serumal 33333 type procollagen peptid (P333P), Ⅳtype collagen peptid (Ⅳ C) , laminin (LN) and hyaluronic acid (HA) in patients with CPH, CAH and LC were jointly determined by applying the kit made in China. The results showed that the levels of four indexes in CAH were respectively 16. 29±3. 58ug/ml; 216. 49±100. 86ng/ml, 196. 87±88.45ng/ml, 147.55± 36. 85ng/ml; in LC were respectively 21. 04±4. 74u/ml, 385. 08±95.76ng/ml, 769. 29±652. 28ng/ml, 182. 56±44. 39ng/ml; in patients with CAH and LC all were significantly higher than in normal people (P<0. 05), and in LC were higher than in CAH. But the levels of four indexes in CPH had not difference with normal people (P> 0. 05) besides HA. Aforesaid results are same as domestic reports written by other authors. The changes of four indexes had not correlation with the increase of ALT, but had obvious correlation with the increase of gamma globulins in serum protein electrophoresis. Therefore, detecting four indexes jointly will be helpful to diagnose LC and observe its therapeutic effect.
出处
《中西医结合肝病杂志》
CAS
1996年第1期1-3,共3页
Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases
关键词
肝硬变
诊断
诊断指标
Hepatocirrhosis Laminin Ⅲ Type Procollagen Pepticl ⅣType Collagen Peptid Hyaluronic Acid
