摘要
目的:观察阿尔茨海默病和血管性痴呆患者血小板功能变化,探讨血小板功能变化在两种疾病中的价值。方法:实验于2001-08/09在北京医院血液科实验室完成。血清标本均来自北京第一社会福利医院住院患者和健康体检者,按照临床阿尔茨海默病和血管性痴呆的诊断标准选取高龄阿尔茨海默病组患者15例,血管性痴呆组患者24例和高龄正常对照组25例。对受检者行肘静脉穿刺取血3mL,与抗凝剂充分混匀,室温静置1h后检测并计算血小板黏附率和血小板聚集率,并进行各组血小板黏附率和聚集率异常百分率的比较。结果:阿尔茨海默病组、血管性痴呆组和正常对照组血小板黏附功能异常比例分别为53%,71%,5%,血小板聚集功能异常比例分别为60%,67%,12%。卡方检验显示三组研究对象血小板黏附和血小板聚集功能异常明显(P<0.01)。结论:阿尔茨海默病患者和血管性痴呆高龄患者血小板黏附和血小板聚集功能异常百分率明显增高,可以作为临床辅助诊断,但是无法用于区分阿尔茨海默病和血管性痴呆患者。
AIM： To investigate the changes of platelet function in patients with Alzheimer disease and vascular dementia and explore the value of the changes of platelet function in this two kinds of diseases. METHODS： The experiment was conducted at the Laboratory of Department of Hematology, Beijing Hospital from August to September 2001. The serum samples were gained from the inpatients and healthy body examination people from Beijing First Social Welfare Hospital. According to the diagnosis standard of clinical Alzheimer disease and vascular dementia, 15 advanced aged patents with Alzheimer disease, 24 patients with vascular dementia and 25 patients with advanced aged people of normal control group were selected. Blood of 3 mL was gained from puncture of vein of elbow and mixed with anticoagulant fully, and then detected after laid silently in room temperature for 1 hour. Platelet adhesion rate （PAdT） and Platelet aggregation rate （PAgT） were measured, and the abnormal percentages of PAdT and PAgT were compared in every group.
RESULTS： The abnormal percentages of PAdT in the Alzheimer disease group, vascular dementia group and normal control group were 53%,71% and 5%, respectively. The abnormal percentages of PAgT were 60% ,67% and 12%, respeetively. The chi-square test showed that the abnormal fimction of PAdT and PAgT was significant in the three groups （P〈0.01）.
CONCLUSION： The abnormal percentages of PAdT and PAgT of high-aged patients with Alzheimer disease and vascular dementia increase significantly, which can be used as clinical assisted diagnosis, but cannot be used to differ from the patients with Alzheimer disease and patients with vascular dementia.
出处
《中国临床康复》
CSCD
北大核心
2005年第45期24-25,共2页
Chinese Journal of Clinical Rehabilitation
